Daisuke Kohno
Gunma University
12 Papers
16 Citations
Daisuke Kohno is an academic researcher from Gunma University. The author has contributed to research in topics: Energy homeostasis & Hypothalamus. The author has an hindex of 7, co-authored 12 publications.
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Papers
SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels
Takayoshi Suga,Osamu Kikuchi,Masaki Kobayashi,Sho Matsui,Hiromi Yokota-Hashimoto,Eri Wada,Daisuke Kohno,Tsutomu Sasaki,Kazusane Takeuchi,Satoru Kakizaki,Masanobu Yamada,Tadahiro Kitamura +11 more
TL;DR: A glucose clamp study revealed that the plasma glucagon increase associated with dapagliflozin could be explained as a response to acute declines in blood glucose, and suggested that a novel mechanism regulated glucagon secretion through SGLT1 in α cells.
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Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance.
Xavier Cyril Brenachot,Giorgio Ramadori,Rafael M. Ioris,Christelle Veyrat-Durebex,Jordi Altirriba,Ebru Aras,Sanda Ljubicic,Daisuke Kohno,Salvatore Fabbiano,Sophie Clément,Nicolas Goossens,Mirko Trajkovski,Sheila Harroch,Francesco Negro,Francesco Negro,Roberto Coppari +15 more
TL;DR: It is shown that hepatic expression of Protein Tyrosine Phosphatase Receptor Gamma (PTPR-γ) is stimulated by inflammation in obese/T2DM mice and positively correlates with indices of inflammation and insulin resistance in humans.
Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.
Eri Wada,Masaki Kobayashi,Daisuke Kohno,Osamu Kikuchi,Takayoshi Suga,Sho Matsui,Hiromi Yokota-Hashimoto,Norikiyo Honzawa,Yuichi Ikeuchi,Haruka Tsuneoka,Touko Hirano,Hideru Obinata,Tsutomu Sasaki,Tadahiro Kitamura +13 more
TL;DR: In this article, the effects of nutrients on glucagon secretion were assessed using islets isolated from diabetic mice and palmitate-treated islets, and the expression levels of branched chain amino acid (BCAA) catabolism-related enzymes and their metabolites in diabetic islets.
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Role of PDK1 in skeletal muscle hypertrophy induced by mechanical load.
Naoki Kuramoto,Kazuhiro Nomura,Daisuke Kohno,Tadahiro Kitamura,Gerard Karsenty,Tetsuya Hosooka,Wataru Ogawa +6 more
TL;DR: This article showed that skeletal muscle-specific deficiency of 3'-phosphoinositide-dependent kinase 1 (PDK1), a key component of PI3K signaling pathway, manifest a reduced skeletal muscle mass under the static condition as well as impairment of mechanical load-induced muscle hypertrophy.
Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis.
Hirotsugu Uzawa,Daisuke Kohno,Tomoaki Koga,Tomoaki Koga,Tsutomu Sasaki,Tsutomu Sasaki,Ayako Fukunaka,Toshiaki Okuno,Airi Jo-Watanabe,Saiko Kazuno,Takeshi Miyatsuka,Tadahiro Kitamura,Yoshio Fujitani,Hirotaka Watada,Kazuko Saeki,Takehiko Yokomizo +15 more
TL;DR: It is indicated that LTA4H mediates the diet‐induced obesity by reducing catecholamine and thyroid hormone secretion.
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