Daisuke Hibi
Gifu University
22 Papers
100 Citations
Daisuke Hibi is an academic researcher from Gifu University. The author has contributed to research in topics: DNA damage & Genotoxicity. The author has an hindex of 14, co-authored 22 publications.
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Papers
Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A.
Daisuke Hibi,Yuta Suzuki,Yuji Ishii,Meilan Jin,Maiko Watanabe,Yoshiko Sugita-Konishi,Tokuma Yanai,Takehiko Nohmi,Akiyoshi Nishikawa,Takashi Umemura +9 more
TL;DR: The results strongly suggest the involvement of a genotoxic mechanism, with the exception of oxidative DNA damage in OTA-induced renal carcinogenesis, and the reporter gene mutation assay using DNA from target sites could be a more powerful tool to investigate in vivo genot toxicities.
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Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression.
Daisuke Hibi,Aki Kijima,Ken Kuroda,Yuta Suzuki,Yuji Ishii,Meilan Jin,Masahiro Nakajima,Yoshiko Sugita-Konishi,Tokuma Yanai,Takehiko Nohmi,Akiyoshi Nishikawa,Takashi Umemura +11 more
TL;DR: A comparative analysis of global gene expression in the renal cortex (COR) and OM of kidneys from gpt delta rats administered OTA at a carcinogenic dose for 4 weeks suggested that OTA induced DSB and cell cycle progression at the target site.
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Ochratoxin A induces DNA double-strand breaks and large deletion mutations in the carcinogenic target site of gpt delta rats.
Ken Kuroda,Daisuke Hibi,Yuji Ishii,Shinji Takasu,Aki Kijima,Kohei Matsushita,Kenichi Masumura,Maiko Watanabe,Yoshiko Sugita-Konishi,Hiroki Sakai,Tokuma Yanai,Takehiko Nohmi,Kumiko Ogawa,Takashi Umemura +13 more
TL;DR: Dramatic increases in the expression of genes involved in G2/M arrest and S/G2 phase were observed, suggesting that DSBs induced by OTA were repaired predominantly by HR repair, possibly due to OTA-specific cell cycle regulation, consequently producing large deletion mutations at the carcinogenic target site.
Role of p53 in the Progression from Ochratoxin A-Induced DNA Damage to Gene Mutations in the Kidneys of Mice
Ken Kuroda,Daisuke Hibi,Yuji Ishii,Yuh Yokoo,Shinji Takasu,Aki Kijima,Kohei Matsushita,Kenichi Masumura,Yukio Kodama,Tokuma Yanai,Hiroki Sakai,Takehiko Nohmi,Kumiko Ogawa,Takashi Umemura +13 more
TL;DR: Results suggested that OTA induced D SBs at the carcinogenic target site in mice and that p53/p21-mediated cell cycle control prevented an increase in the formation of DSBs, leading to gene mutations.
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Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.
Meilan Jin,Aki Kijima,Yuta Suzuki,Daisuke Hibi,Tomoki Inoue,Yuji Ishii,Takehiko Nohmi,Akiyoshi Nishikawa,Kumiko Ogawa,Takashi Umemura +9 more
TL;DR: The overall data suggested that the present model might be a promising candidate for investigating comprehensive toxicities of the agents and data demonstrating the base modification and cell proliferation due to exposure to safrole could contribute to understanding safrole-induced hepatocarcinogenesis.
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