Daigo Asano
Kyoto University
7 Papers
74 Citations
Daigo Asano is an academic researcher from Kyoto University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
•Journal Article
18F-FDG Accumulation in Atherosclerotic Plaques: Immunohistochemical and PET Imaging Study
Mikako Ogawa,Seigo Ishino,Takahiro Mukai,Daigo Asano,Noboru Teramoto,Hiroshi Watabe,Nobuyuki Kudomi,Masashi Shiomi,Yasuhiro Magata,Hidehiro Iida,Hideo Saji +10 more
TL;DR: The results suggest that macrophages are responsible for the accumulation of (18)F-FDG in atherosclerotic lesions, which should be useful for the selective detection of vulnerable plaques.
336
Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability--analysis in hypercholesterolemic rabbits.
Seigo Ishino,Takahiro Mukai,Noriaki Kume,Daigo Asano,Mikako Ogawa,Yuji Kuge,Manabu Minami,Toru Kita,Masashi Shiomi,Hideo Saji +9 more
TL;DR: Results indicate that enhanced LOX-1 expression was associated with histologically unstable atherosclerotic plaques in hypercholesterolemic rabbits, suggesting the involvement of LOx-1 in the destabilization of atherosclerosis in vivo.
87
•Journal Article
Therapeutic Effects of a 186Re-Complex–Conjugated Bisphosphonate for the Palliation of Metastatic Bone Pain in an Animal Model
Kazuma Ogawa,Takahiro Mukai,Daigo Asano,Hidekazu Kawashima,Seigo Kinuya,Kazuhiro Shiba,Kazuyuki Hashimoto,Hirofumi Mori,Hideo Saji +8 more
TL;DR: Evaluation of the therapeutic effects of (186)Re-MAG3-HBP using an animal model of bone metastasis indicates that it could be useful as a therapeutic agent for the palliation of metastatic bone pain.
46
Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors
Hirofumi Hanaoka,Hirofumi Hanaoka,Takahiro Mukai,Takahiro Mukai,Sayo Habashita,Daigo Asano,Kazuma Ogawa,Yoshihiro Kuroda,Hiromichi Akizawa,Yasuhiko Iida,Keigo Endo,Tsuneo Saga,Hideo Saji +12 more
TL;DR: In tumor-bearing mice, a significant correlation was observed between the accumulation in the tumor as well as tumor-to-blood ratio of (111)In-DTPA-CTT and gelatinase activity and these findings support the validity of the chemical design of ( 111) in- DTPA- CTT for reducing accumulation in nontarget tissues and maintaining the inhibitory activity of the mother compound.
33
Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
Daigo Asano,Koichi Nakamura,Yumi Nishiya,Hideyuki Shiozawa,Hideo Takakusa,Takahiro Shibayama,Shin-ichi Inoue,Tsuyoshi Shinozuka,Takakazu Hamada,Chizuko Yahara,Nobuaki Watanabe,Kouichi Yoshinari +11 more
TL;DR: The results suggest that PBPK modeling incorporating pharmacokinetic parameters obtained with PXB-mice is useful for quantitatively predicting exposure to human disproportionate metabolites, and adds to the growing knowledge regarding metabolite exposure estimation by static and dynamic models.
3