Dagmar Barz
University of Jena
57 Papers
238 Citations
Dagmar Barz is an academic researcher from University of Jena. The author has contributed to research in topics: Candida albicans & Biology. The author has an hindex of 28, co-authored 57 publications. Previous affiliations of Dagmar Barz include Schiller International University.
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Papers
Cannflavins from hemp sprouts, a novel cannabinoid-free hemp food product, target microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase
Oliver Werz,Julia Seegers,Anja M. Schaible,Christina Weinigel,Dagmar Barz,Andreas Koeberle,Gianna Allegrone,Federica Pollastro,Lorenzo Zampieri,Gianpaolo Grassi,Giovanni Appendino +10 more
TL;DR: In this article, the authors found that sprouting, while not triggering the production of cannabinoids, could nevertheless induce the anti-inflammatory prenylflavonoids cannflavins A and B. This effect was especially marked in Ermo, a cannabinoid-free variety of Cannabis sativa L.
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Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages.
Silvia Slesiona,Markus Gressler,Michael Mihlan,Christoph Zaehle,Martin Schaller,Dagmar Barz,Bernhard Hube,Bernhard Hube,Ilse D. Jacobsen,Matthias Brock +9 more
TL;DR: It is shown that Aspergillus terreus and A. fumigatus have evolved significantly different strategies to survive the attack of host immune cells, but conidia show long-term persistence in macrophages even in immunocompetent hosts.
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.
Thomas Hanke,Friederike Dehm,Stefanie Liening,Sven-Desiderius Popella,Jonas Maczewsky,Jonas Maczewsky,Max Pillong,Jens Kunze,Christina Weinigel,Dagmar Barz,Astrid Kaiser,Mario Wurglics,Michael Lämmerhofer,Gisbert Schneider,Lidia Sautebin,Manfred Schubert-Zsilavecz,Oliver Werz +16 more
TL;DR: Together, 2-aminothiazole-featured pirinixic acids represent potent dual 5-LO/mPGES-1 inhibitors with an attractive pharmacological profile as anti-inflammatory drugs.
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Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages.
Lydia Kasper,Katja Seider,Franziska Gerwien,Stefanie Allert,Sascha Brunke,Tobias Schwarzmüller,Lauren Ames,Cristina Zubiria-Barrera,Michael K. Mansour,Ulrike Becken,Dagmar Barz,Jatin M. Vyas,Norbert Reiling,Albert Haas,Ken Haynes,Karl Kuchler,Bernhard Hube +16 more
TL;DR: It is shown that phagosomes containing viable C. glabrata cells do not fuse with pre-labeled lysosomes and possess low phagosomal hydrolase activity, and the lack of fungal mannosyltransferases resulted in severely reduced alkalinization in vitro and in the delivery of C.glabRata to acidified phagosome pH.
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).
Erden Banoglu,Burcu Çalışkan,Susann Luderer,Gokcen Eren,Yağmur Özkan,Wolfram Altenhofen,Christina Weinigel,Dagmar Barz,Jana Gerstmeier,Carlo Pergola,Oliver Werz +10 more
TL;DR: The benzimidazole scaffold bearing an ibuprofen fingerprint as a new chemotype for further development of anti-leukotriene agents is disclosed.
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