Dag Jenssen
Stockholm University
70 Papers
1.6K Citations
Dag Jenssen is an academic researcher from Stockholm University. The author has contributed to research in topics: Homologous recombination & Chinese hamster. The author has an hindex of 27, co-authored 70 publications. Previous affiliations of Dag Jenssen include Kerman Medical University.
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Papers
Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.
Cecilia Lundin,Klaus Erixon,Catherine Arnaudeau,Niklas Schultz,Dag Jenssen,Mark Meuth,Thomas Helleday,Thomas Helleday +7 more
TL;DR: It is shown that the arrest of replication with hydroxyurea generates DNA fragmentation as a consequence of the formation of DSBs at newly replicated DNA.
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The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested.
Dag Jenssen,Claes Ramel +1 more
TL;DR: The finding that the combination of Ames's test and the micronucleus test did increase the screening procedure for the prediction of carcinogenic effects is emphasized by the finding that it is an in vivo method, which may pick up effects at the chromosomal level not covered by bacterial assays.
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Brominated flame retardants induce intragenic recombination in mammalian cells.
TL;DR: The findings indicate that the modern additives to plastic, i.e., HBCD and PBDEs, as well as the plastic monomer BCPS may have the same effect to human health as DDT and PCBs, in terms of inducing genetic recombination, which is known to provoke a number of diseases, including cancer.
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The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
Ali Z. Al-Minawi,Yin-Fai Lee,Daniel Håkansson,Fredrik Johansson,Cecilia Lundin,Nasrollah Saleh-Gohari,Niklas Schultz,Dag Jenssen,Helen E. Bryant,M Meuth,John M. Hinz,Thomas Helleday +11 more
TL;DR: It is reported that mitomycin C-induced lesions inhibit replication fork elongation and suggested that ERCC1–XPF plays a role in completion of HR in ICL repair, and no additional sensitivity to cisplatin by siRNA co-depletion of XRCC3 and ER CC1 is found, showing that the two proteins act on the same pathway to promote survival.
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Dose response at low doses of X-irradiation and MMS on the induction of micronuclei in mouse erythroblasts.
Dag Jenssen,Claes Ramel +1 more
TL;DR: The test of induced micronuclei in erythrocytes of mammalian bone marrow constitutes a suitable method for the screening of induced chromosomal lesions at very low dosages of chemicals or irradiations, and suggests that X-irradiation does not interfere with the repair process operating with MMS.
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