Da Ting Lin
Johns Hopkins University School of Medicine
11 Papers
2 Citations
Da Ting Lin is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: AMPA receptor & Synaptic plasticity. The author has an hindex of 9, co-authored 11 publications.
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Papers
Synapse-specific regulation of AMPA receptor function by PSD-95
TL;DR: A synapse-specific role for PSD-95 in controlling synaptic function that is independent of spine morphology is suggested, which is related to the greater magnitude of potentiation after long-term potentiation induction observed in these mice.
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Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
Da Ting Lin,Yuichi Makino,Kamal Sharma,Takashi Hayashi,Rachael L. Neve,Kogo Takamiya,Kogo Takamiya,Richard L. Huganir +7 more
TL;DR: A previously unknown mechanism that governs activity-dependent GluR1 trafficking is uncovered, an interaction between AMPAR palmitoylation and phosphorylation is revealed, and the functional importance of 4.1N in AMPAR trafficking and synaptic plasticity is underscored.
379
Excess of De Novo Deleterious Mutations in Genes Associated with Glutamatergic Systems in Nonsyndromic Intellectual Disability
Fadi F. Hamdan,Julie Gauthier,Yoichi Araki,Da Ting Lin,Yuhki Yoshizawa,Kyohei Higashi,A-Reum Park,Dan Spiegelman,Sylvia Dobrzeniecka,Amélie Piton,Hideyuki Tomitori,Hussein Daoud,Christine Massicotte,Edouard Henrion,Ousmane Diallo,Masoud Shekarabi,Claude Marineau,Michael Shevell,Bruno Maranda,Grant A. Mitchell,Amélie Nadeau,Guy D'Anjou,Michel Vanasse,Myriam Srour,Ronald G. Lafrenière,Pierre Drapeau,Jean-Claude Lacaille,Eunjoon Kim,Jae-Ran Lee,Kazuei Igarashi,Richard L. Huganir,Guy A. Rouleau,Jacques L. Michaud +32 more
TL;DR: In this article, de novo mutations (DNMs) in synaptic genes explain an important fraction of sporadic nonsyndromic intellectual disability (NSID) cases, finding 11 DNMs, including ten potentially deleterious mutations (three nonsense, two splicing, one frameshift, four missense) and one neutral mutation (silent).
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PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization.
Da Ting Lin,Richard L. Huganir +1 more
TL;DR: It is demonstrated that internalized pH-GluR2 subunits recycle back to the cell surface after NMDAR activation and that neurons lacking PICK1 display normal NMDar dependent GluR 2 internalization compared with wild-type neurons, but demonstrate accelerated GLUR2 recycling after N MDAR activation.
183
Visualization of NMDA receptor - Dependent AMPA receptor synaptic plasticity in vivo
TL;DR: In vivo two-photon microscopy in the mouse somatosensory barrel cortex found that acute whisker stimulation led to a significant increase in the intensity of surface AMPAR GluA1 subunit (sGluA 1) in both spines and dendritic shafts and a small increase in spine size relative to prestimulation values.