https://www.pnas.org/content/pnas/61/2/708.full.pdf

The cross-linking of collagen and elastin: enzymatic conversion of lysine in peptide linkage to alpha-aminoadipic-delta-semialdehyde (allysine) by an extract from bone.

We studied several members of a family with an X-linked form of cutis laxa; the affected males have mild skin laxity, a characteristic facies, skeletal abnormalities, structural abnormalities of the genitourinary tract, and low serum copper levels. The activity of lysyl oxidase, a copper-dependent enzyme involved in cross-link formation in collagen, was decreased in skin-biopsy specimens (13 to 26 per cent of normal) and in culture medium from cells of two affected males (15 to 20 per cent of normal). Immunoreactive lysyl oxidase from skin of both patients was virtually undetectable by immunodiffusion assay. The amounts of lysyl-derived aldehydes (the product formed in collagen and elastin by lysyl oxidase) and of cross-links formed from these products were decreased in dermal fibroblasts in culture. Collagen extractability from these cells was increased in culture. These findings suggest that lysyl oxidase deficiency provides the biochemical basis of the X-linked form of cutis laxa. (N Engl J Me...

X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity.

Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.

Article de synthese traitant des aspects fonctionnels biochimiques du cuivre chez l'animal et des parametres biochimiques d'une deficience en cuivre. Homeostasie. Cuproenzymes. Cuproproteines. Carence en cuivre: changements biochimiques et pathologiques. Specificite de sensibilite des organes et des cuproenzymes au deficit en Cu

Biochemical changes in copper deficiency.

Cardiovascular studies on copper deficient swine. XII. Partial purification of a soluble protein resembling elastin.

Composition of aortic tissue from copper-deficient chicks.

Comparison of Copper Deficiency and Lathyrism in Turkey Poults

SummaryThe effect of copper deficiency and a dietary lathyrogen (BAPN) on the amine oxidase activity of various tissues in growing chicks was investigated. The benzylamine oxidase activity of aorta, heart and kidney was decreased in copper-deficient chicks compared to copper-supplemented chicks while the activity of liver was not affected. Copper added in vitro partially restored the activity of deficient aortic tissue. Dietary BAPN had no effect on aortic benzylamine oxidase activity but in vitro addition of BAPN competitively inhibited the enzyme. Ascorbic acid in vitro also inhibited the activity of aortic benzylamine oxidase but in a non-competitive manner.

Effect of copper deficiency and inhibitors on the amine oxidase activity of chick tissues.

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Composition of aortic tissue from copper-deficient chicks.

Comparison of Copper Deficiency and Lathyrism in Turkey Poults

Effect of copper deficiency and inhibitors on the amine oxidase activity of chick tissues.