D. Vernon Rayner
Rowett Research Institute
19 Papers
271 Citations
D. Vernon Rayner is an academic researcher from Rowett Research Institute. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of D. Vernon Rayner include University of Aberdeen.
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Papers
Circulating Leptin Levels Are Modulated by Fasting, Cold Exposure and Insulin Administration in Lean but Not Zucker (fa/fa) Rats as Measured by ELISA
TL;DR: A sensitive enzyme-linked immunosorbent assay (ELISA) is described for the quantitation of plasma leptin levels in both mice and rats, finding that leptin levels were unchanged in fa/fa rats exposed to the same physiological stimuli.
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Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice.
TL;DR: Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm, and Regulation of receptor gene expression may be an important component in the reading of the leptin signal.
145
Normal distribution of body weight gain in male Sprague-Dawley rats fed a high-energy diet
TL;DR: There was no segregation into two distinct populations on the basis of susceptibility to diet-induced obesity in outbred male Sprague-Dawley rats, and body weight and other measured parameters were normally distributed.
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Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status.
Sharon E. Mitchell,Rubén Nogueiras,Rubén Nogueiras,Amanda C. Morris,Sulay Tovar,Christine Grant,Morven Cruickshank,D. Vernon Rayner,Carlos Dieguez,Carlos Dieguez,Lynda M. Williams +10 more
TL;DR: Early loss of leptin sensitivity after high‐fat feeding is unrelated to down‐regulation of leptin receptor expression or number and does not involve the JAK/STAT pathway.
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Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor α-methyl-p-tyrosine
TL;DR: It is suggested that sympathetic tone plays a pivotal role in regulating leptin production, and inhibition of noradrenaline synthesis leads to the rapid induction of hyperleptinaemia.
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