D. Thomas
University Hospital Heidelberg
14 Papers
76 Citations
D. Thomas is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Potassium channel & Membrane potential. The author has an hindex of 10, co-authored 14 publications.
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Papers
Novel roles for hERG K(+) channels in cell proliferation and apoptosis.
TL;DR: Molecular mechanisms of hERG-associated cell cycle regulation and cell death are discussed and the significance ofhERG K+ channels as future drug target in anticancer therapy is highlighted.
cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control.
Patrick A. Schweizer,Nana Duhme,D. Thomas,Rüdiger Becker,Joerg Zehelein,Andreas Draguhn,Claus Bruehl,Hugo A. Katus,Michael Koenen +8 more
TL;DR: In humans, cAMP responsiveness of If determines basal heart rate but is not critical for maximum heart rate, heart rate variability, or chronotropic competence, whereas cAMP-activated If may stabilize heart rhythm during chronotropic response.
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TASK1 (K2P3.1) K+ channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation
Claudia Seyler,E Duthil-Straub,Edgar Zitron,Jakob Gierten,Eberhard P. Scholz,Rainer H. A. Fink,Christoph A. Karle,Rüdiger Becker,Hugo A. Katus,D. Thomas +9 more
TL;DR: This study was designed to elucidate molecular mechanisms underlying inhibition of TASK1 channels by endothelin‐1, an established target of pulmonary arterial hypertension therapy.
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Carvedilol targets human K2P3.1 (TASK1) K+ leak channels
Kathrin Staudacher,Ingo Staudacher,Eckhard Ficker,Claudia Seyler,Jakob Gierten,Jana Kisselbach,Ann-Kathrin Rahm,Kerstin Trappe,Patrick A. Schweizer,Ruediger Becker,Hugo A. Katus,D. Thomas +11 more
TL;DR: The objective of this study was to investigate acute effects of carvedilol on human K2P3.1 (hK2P 3.1) channels.
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Prevalence, kinetic changes and possible reasons of elevated cardiac troponin T in patients with AV nodal re-entrant tachycardia.
M. Schueler,Mehrshad Vafaie,Ruediger Becker,Moritz Biener,D. Thomas,Matthias Mueller,Evangelos Giannitsis,Hugo A. Katus +7 more
TL;DR: AVNRT is a possible reason for elevated cardiac troponin T, even in the absence of relevant structural heart disease or CAD, as seen in patients with and withoutStructural heart disease.
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