D Saunders
Smith, Kline & French
15 Papers
57 Citations
D Saunders is an academic researcher from Smith, Kline & French. The author has contributed to research in topics: ATPase & Bicyclic molecule. The author has an hindex of 5, co-authored 15 publications.
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Papers
Photoaffinity labeling of the lumenal K+ site of the gastric (H+ + K+)-ATPase.
TL;DR: A photoaffinity label for the lumenal K+ site of the gastric (H+ + K+)-ATPase has been identified and tryptic digestion of gastric vesicle membranes failed to release the radioactivity from the membranes suggesting that the site of interaction was close to or within the membrane-spanning sections of this ion pump.
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Syntheses of 14C‐labelled prizidilol dihydrochloride
D Saunders,B H Warrington +1 more
TL;DR: In this paper, two synthesized radiolabelled prizidilol dihydrochloride (DL)3-[2-(3-t-butylamino -2-hydroxypropoxy)phenyl]-6-hydrazino-pyridazine dihydronide) are described.
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The preparation of 14C, 35S and 13C labelled forms of omeprazole
TL;DR: The first three compounds were prepared from the approprlate isotopically labelled carbon disulphide as discussed by the authors, and the key step in the synthesis of [2-pyridyl-14C-methyl]omeprazole is nucleophilic alkylation of a 1-ethoxypyridinium salt using [14C]methyl magnesium idodide.
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The synthesis of [14C]pantoprazole - SK&F 96022Z. An H+/K+ ATPase inhibitor
TL;DR: Pantoprazole 1, SK & F 96022Z, an H+/K+ ATPase inhibitor has been prepared, radiolabelled with carbon-14, in two positions, for drug metabolism studies.
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Synthesis of [14C]imidazole ring labeled metiamide, cimetidine and impromidine
TL;DR: In this paper, the radiosynthesis of imidazole ring labeled [14C]metiamide, [ 14C]cimetidine and [14c]impromidine is described involving the reaction of the key common intermediate 2-[[(4-methyl-1H]-2-14C]-imidazol-5-yl)methyl]thio]ethanamine (5) with methyl isothiocyanate, dimethyldithiocynoiminocyanoimINocarbonate/methylamine
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