D.P. von Kessler
Johns Hopkins University
9 Papers
65 Citations
D.P. von Kessler is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Ultrabithorax & Homeobox. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of D.P. von Kessler include University of Washington & Johns Hopkins University School of Medicine.
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Papers
Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites.
TL;DR: A multisite integrative model of homeotic protein action is proposed in which functional regulatory elements can be built from many lower-affinity sites, or from sites of some intermediate number and affinity, consistent with reports that homeodomain protein targets contain multiple individual binding site sequences distributed throughout sizable DNA regions.
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pH-Dependent Enhancement of DNA Binding by the Ultrabithorax Homeodomain†
TL;DR: Enhanced DNA binding affinity at lower pH for the Ubx-HD in vitro is demonstrated and the potential for significant discrimination of DNA binding sites in vivo is suggested.
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Autoproteolysis in hedgehog protein biogenesis.
TL;DR: The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor.
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
TL;DR: It is shown that amino acid residues within the N‐terminal arm are responsible for the sequence specificity differences between the Ultrabithorax and Abdominal‐B homeodomains, suggesting that differential DNA sequence recognition may play a role in HOM protein function in a wide range of organisms.