D. P. Behan
University of Reading
7 Papers
34 Citations
D. P. Behan is an academic researcher from University of Reading. The author has contributed to research in topics: Receptor & Corticotropin-releasing hormone. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of D. P. Behan include Salk Institute for Biological Studies.
Chat about Author
Papers
Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal human pregnancy.
Elizabeth A. Linton,Anthony V. Perkins,R. J. Woods,F. Eben,Charles D.A. Wolfe,D. P. Behan,E. Potter,W Vale,P. J. Lowry +8 more
TL;DR: There is an increase in the availability of free, potentially bioactive CRH at term to stimulate the release of ACTH from the maternal pituitary and/or to act at a peripheral, non-pituitary CRH receptor(s).
197
Corticotropin-releasing factor binding protein dimerizes after association with ligand.
TL;DR: It is shown that association of human CRF to this BP results in an increase in molecular weight consistent with the formation of a dimer form of the BP ligand complex and suggests that this dimerization occurs in vivo when CRF is released into the bloodstream and provides the trigger that causes the uptake of the complex at specific receptor sites.
28
Circulating corticotropin-releasing factor in pregnancy.
TL;DR: Elevated levels of CRF in the plasma of women in the third trimester of pregnancy are described and great variation exists in the absolute levels of the peptide measured and this may reflect the different assay and extraction systems used.
7
Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.
Ellen Potter,D. P. Behan,D. P. Behan,Wolfgang H. Fischer,Elizabeth A. Linton,Philip J. Lowry,Wylie Vale +6 more
TL;DR: In this article, the authors reported the existence of a CRF-binding protein in human plasma which inactivates CRF and which has been proposed to prevent inappropriate pituitaryadrenal stimulation in pregnancy.
A specific carrier substance for human corticotrophin releasing factor in late gestational maternal plasma which could mask the ACTH-releasing activity.
TL;DR: Using gel chromatography and CRF‐41 immunoradiometric assay, it is shown that binding of the peptide to its plasma carrier can be disrupted by treatment with urea, and the more concentrated chromatographic fractions at the apex of the carrier‐bound CRf‐41 peak showed reduced bioactivity, indicating that the higher concentrations of carrier in the original maternal plasma could mask the ACTH‐releasing activity of CRF•41.