D. L. Budenz
University of North Carolina at Chapel Hill
4 Papers
13 Citations
D. L. Budenz is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Genome-wide association study & Ocular hypertension. The author has an hindex of 4, co-authored 4 publications.
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Papers
Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
Sumana R Chintalapudi,Doaa Nabih Maria,Doaa Nabih Maria,Xiang Di Wang,Jessica N. Cooke Bailey,R. Rand Allingham,Murray H. Brilliant,D. L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Jonathan L. Haines,Lisa A Hark,Michael A. Hauser,Robert P. Igo,Jae H. Kang,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Louis R. Pasquale,Margaret A. Pericak-Vance,Anthony Realini,Doug Rhee,Julia R. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Gadi Wollstein,Donald J. Zack,Tin Aung,Peter Bonnemaijer,Cheng Yu Cheng,Jamie E Craig,Cornelia M. van Duijn,Puya Gharahkhani,Adriana I. Iglesias Gonzalez,Christopher J Hammond,Alex W. Hewitt,René Hoehn,Fridbert Jonansson,Anthony P Khawaja,Chiea Chuen Khor,Caroline C W Klaver,Andrew J. Lotery,David A. Mackey,Stuart MacGregor,Calvin C P Pang,Francesca Pasutto,Kari Stefansson,Gudmar Thorleifsson,Unnar Thorsteinsdottir,Veronique Vitart,Eranga N. Vithana,Terri L. Young,Tanja Zeller,Pirro G. Hysi,Janey L. Wiggs,Robert W. Williams,Monica M. Jablonski +63 more
TL;DR: The authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal models and demonstrate that the systems genetics approach represents an efficient method to identify genetic variation that can guide the selection of therapeutic targets.
Ocular hypotensive effect of fixed-combination brinzolamide/brimonidine adjunctive to a prostaglandin analog: a randomized clinical trial
TL;DR: Therapy with BBFC produced an additive IOP-lowering effect compared with a PGA alone or in conjunction with vehicle, and may provide an effective treatment option for patients receiving PGA monotherapy who require additional IOP reduction.
Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus
Baojian Fan,Xueli Chen,Nisha Sondhi,P. Ferdinamarie Sharmila,Nagasamy Soumittra,Sarangapani Sripriya,Srinivasan Sacikala,Rashima Asokan,David S. Friedman,Louis R. Pasquale,X. Raymond Gao,Lingam Vijaya,Jessica N. Cooke Bailey,Veronique Vitart,Stuart MacGregor,Christopher J Hammond,Chiea Chuen Khor,Jonathan L. Haines,Ronnie George,Janey L. Wiggs,R. Rand Allingham,Jim Gauderman,Michael A. Hauser,Jerome I. Rotter,Rohit Varma,Tin Aung,Kathryn P. Burdon,Ching-Yu Cheng,Jamie E Craig,Angela J. Cree,Puya Gharahkhani,Alex W. Hewitt,René Höhn,Pirro G. Hysi,Adriana I. Iglesias Gonzalez,Jost B. Jonas,Anthony P Khawaja,Caroline C W Klaver,Francesca Pasutto,David A. Mackey,Paul Mitchell,Aniket Mishra,Calvin C P Pang,Henriette Springelkamp,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Ananth C. Viswanathan,Robert Wojciechowski,Tien Wong,Terri L. Young,Tanja Zeller,Murray H. Brilliant,D. L. Budenz,John H. Fingert,Douglas E. Gaasterland,Terry Gaasterland,Robert P. Igo,Jae H. Kang,Peter Kraft,Richard K. Lee,Paul R. Lichter,Yutao Liu,S.E. Moroi,Anthony Realini,Doug Rhee,Julia R. Richards,Robert Ritch,Joel S. Schuman,William K. Scott,Kuldev Singh,Arthur J. Sit,Douglas Vollrath,Robert N. Weinreb,Gadi Wollstein,Donald J. Zack +75 more
TL;DR: An ocular phenome-wide association study for the top WNT7B SNPs using 45 ocular traits measured in these same families including corneal curvature and axial length indicates that in the South Indian families WNT6B SNP are primarily associated with CCT, and suggests that W NT7BSNPs can have population-specific effects on ocular quantitative traits.
Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma
Jae H. Kang,Stephanie Loomis,Brian L. Yaspan,Jessica N. Cooke Bailey,Robert N. Weinreb,Richard K. Lee,Paul R. Lichter,D. L. Budenz,Yutao Liu,Tony Realini,Douglas E. Gaasterland,Terry Gaasterland,David S. Friedman,Catherine A. McCarty,S.E. Moroi,Lana M. Olson,Joel S. Schuman,Kuldev Singh,Douglas Vollrath,Gadi Wollstein,Donald J. Zack,Murray H. Brilliant,Arthur J. Sit,William G. Christen,John H. Fingert,John P. Forman,Emmanuel S. Buys,Peter Kraft,Kang Zhang,R. Rand Allingham,Margaret A. Pericak-Vance,Julia E. Richards,Michael A. Hauser,Jonathan L. Haines,Janey L. Wiggs,Louis R. Pasquale +35 more
TL;DR: Although the assembled vascular tone SNP set was not associated with POAG, genes that code for local factors involved in setting vascular tone were associated withPOAG.