D Kata
University of Szeged
16 Papers
4 Citations
D Kata is an academic researcher from University of Szeged. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 4, co-authored 8 publications.
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Papers
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance
Réka Spohn,Lejla Daruka,Lejla Daruka,Viktória Lázár,Viktória Lázár,Ana Martins,Fanni Vidovics,Gábor Grézal,Orsolya Méhi,Bálint Kintses,Bálint Kintses,Mónika Számel,Mónika Számel,Pramod Kumar Jangir,Pramod Kumar Jangir,Bálint Csörgő,Bálint Csörgő,Ádám Györkei,Zoltán Bódi,Anikó Faragó,László Bodai,Imre Földesi,D Kata,Gergely Maróti,Bernadett Pap,Roland Wirth,Balázs Papp,Csaba Pál +27 more
TL;DR: This work indicates that evolution of resistance against certain AMPs, such as tachyplesin II and cecropin P1, is limited, and physicochemical features that make AMPs less prone to resistance and no cross- or horizontally-acquired resistance are found.
Rational design of balanced dual-targeting antibiotics with limited resistance.
Ákos Nyerges,Tihomir Tomašič,Martina Durcik,Tamás Révész,Tamás Révész,Petra Szili,Petra Szili,Gábor Draskovits,Ferenc Bogár,Žiga Skok,Nace Zidar,Janez Ilaš,Anamarija Zega,Danijel Kikelj,Lejla Daruka,Lejla Daruka,Balint Kintses,Bálint Vásárhelyi,Imre Földesi,D Kata,Martin Welin,Raymond Kimbung,Dorota Focht,Lucija Peterlin Mašič,Csaba Pál +24 more
TL;DR: It is demonstrated that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workflow and lead compounds, ULD1 and ULD2, belonging to a novel chemical class, almost equipotently inhibit bacterial DNA gyrase and topoisomerase IV complexes and interact with multiple evolutionary conserved amino acids in the ATP-binding pockets of their target proteins.
Potent Chimeric Antimicrobial Derivatives of the Medicago truncatula NCR247 Symbiotic Peptide.
Sándor Jenei,Hilda Tiricz,János Szolomájer,Edit Tímár,Éva Klement,Mohamad Anas Al Bouni,Rui M. Lima,D Kata,Maria Harmati,Krisztina Buzas,Krisztina Buzas,Imre Földesi,Gábor Tóth,Gabriella Endre,Eva Kondorosi +14 more
TL;DR: The chimeric derivatives obtained by fusion of NCR247C with other peptide fragments and particularly with a truncated mastoparan sequence significantly increased bactericidal activity and altered the antimicrobial spectrum.
Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104.
Noémi Lajkó,D Kata,Melinda Szabó,Adrienne Mátyás,Karolina Dulka,Imre Földesi,Ferenc Fülöp,Karoly Gulya,László Vécsei,András Mihály +9 more
TL;DR: Although kynurenic acid and its analogues proved to be glutamate receptor antagonists, their immunosuppressive action was dominant in epilepsy and the inhibition of phagocytosis in vitro raised the possibility of the inhibited of genes encoding inflammatory cytokines in microglial cells.
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Rationally designed foldameric adjuvants enhance antibiotic efficacy via promoting membrane hyperpolarization
Kaushik Nath Bhaumik,Csaba Pál,Anasztázia Hetényi,Gábor Olajos,Ana Martins,Réka Spohn,Lukács Németh,Balázs Jójárt,Petra Szili,Petra Szili,Anett Dunai,Pramod Kumar Jangir,Lejla Daruka,Lejla Daruka,Imre Földesi,D Kata,Csaba Pál,Tamás A. Martinek +17 more
- 01 Jan 2022
TL;DR: Inspired by the molecular scaffold of the antimicrobial peptide PGLa, the authors developed antimicrobial foldamers with a computer-guided design strategy, which induce sustained membrane hyperpolarization.