D. K. Raap
Loyola University Chicago
14 Papers
282 Citations
D. K. Raap is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Oxytocin & Hypothalamus. The author has an hindex of 12, co-authored 14 publications. Previous affiliations of D. K. Raap include University of Alaska Fairbanks.
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Papers
5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells.
TL;DR: The combined neuroanatomical and pharmacological observations suggest that the neuroendocrine responses to DOI are mediated by activation of neurons in the hypothalamic paraventricular nucleus and associated circuitry.
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Estrogen desensitizes 5-HT1A receptors and reduces levels of Gz, Gi1 and Gi3 proteins in the hypothalamus
D. K. Raap,Lydia L. DonCarlos,Francisca Garcia,Nancy A. Muma,William A. Wolf,George Battaglia,Louis D. Van de Kar +6 more
TL;DR: The present results suggest that estrogen or estrogen-like substances in combination with SSRIs may prove effective in developing novel therapeutic strategies for neuropsychiatric disorders in women.
111
Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats.
Yahong Zhang,D. K. Raap,Francisca Garcia,Florence Serres,Qing Ma,George Battaglia,Louis D. Van der Kar +6 more
TL;DR: It is suggested that neuroadaptive changes induced by sustained inhibition of serotonin (5-HT) reuptake, contribute to the mechanism of the anxiolytic effects of fluoxetine, in contrast to the neuroendocrine responses to conditioned stress, which are not affected by these neuro Adaptive changes.
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•Journal Article
Daily Injections of Fluoxetine Induce Dose-Dependent Desensitization of Hypothalamic 5-HT1A Receptors: Reductions in Neuroendocrine Responses to 8-OH-DPAT and in Levels of Gz and Gi Proteins
D. K. Raap,S. Evans,Francisca Garcia,Qian Li,Nancy A. Muma,W A Wolf,George Battaglia,L.D. Van de Kar +7 more
TL;DR: The results from the present study indicate that fluoxetine-induced desensitization of hypothalamic postsynaptic 5-HT1A receptor systems is dose-dependent and may be caused in part by reductions in the hypothalamic levels of Gz proteins.
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Evidence that G(z)-proteins couple to hypothalamic 5-HT(1A) receptors in vivo.
Florence Serres,Qian Li,Francisca Garcia,D. K. Raap,George Battaglia,Nancy A. Muma,L.D. Van de Kar +6 more
TL;DR: P pertussis toxin-sensitive Gi/Go-proteins do not mediate the 5-HT1A receptor-mediated increase in ACTH and oxytocin secretion, and these studies provide the firstin vivo evidence for a key role of Gz- Proteins in coupling hypothalamic 5- HT1Areceptors to effector mechanisms.
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