We infused 111-Indium conjugated murine monoclonal antibodies into 37 patients with various malignancies. One patient with breast cancer received a human IgM conjugate. At least one known site of tumor was imaged in 75% of patients, and 50% of all known lesions were successfully imaged. In 6 patients, lesions were detected which had not been previously appreciated. There was no toxicity except in patients in whom the antibody cross-reacted with circulating cells. Isotope was concentrated nonspecifically in the liver of all patients. These studies confirm the feasibility of immunoscintigraphy, but emphasize several problem areas for radioimmunotherapy.

Immunoscintigraphy with 111-Indium Conjugated Monoclonal Antibodies

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Immunoscintigraphy with 111-Indium Conjugated Monoclonal Antibodies