https://www.jto.org/article/S1556-0864(15)00025-8/pdf

Contemporary Analysis of Prognostic Factors in Patients with Unresectable Malignant Pleural Mesothelioma.

The Controlling Nutritional Status Score Is a Significant Independent Predictor of Poor Prognosis in Patients With Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a disease with limited therapeutic options, the management of which is still controversial. Diagnosis is usually made by thoracoscopy, which allows multiple biopsies with histological subtyping and is indicated for staging purposes in surgical candidates. The recommended and recently updated classification for clinical use is the TNM staging system established by the International Mesothelioma Interest Group and the International Association for the Study of Lung Cancer, which is based mainly on surgical and pathological variables, as well as on cross-sectional imaging. Contrast-enhanced computed tomography is the primary imaging procedure. Currently, the most used measurement system for MPM is the modified Response Evaluation Criteria in Solid Tumors (RECIST) method, which is based on unidimensional measurements of tumor thickness perpendicular to the chest wall or mediastinum. Magnetic resonance imaging and functional imaging with 18F-fluoro-2-deoxy-D-glucose positron-emission tomography can provide additional staging information in selected cases, although the usefulness of this method is limited in patients undergoing pleurodesis. Molecular reclassification of MPM and gene expression or miRNA prognostic models have the potential to improve prognostication and patient selection for a proper treatment algorithm; however, they await prospective validation to be introduced in clinical practice.

/pdf/clinical-staging-of-malignant-pleural-mesothelioma-current-2upu024lby.pdf

Clinical staging of malignant pleural mesothelioma: current perspectives.

// Long Tian 1, * , Rujun Zeng 2, * , Xin Wang 1, * , Cheng Shen 1 , Yutian Lai 1 , Mingming Wang 1 and Guowei Che 1 1 Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China 2 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China * These authors have contributed equally to this work Correspondence to: Guowei Che, email: guowei_che@yahoo.com Keywords: soluble mesothelin, malignant pleural mesothelioma, prognosis, meta-analysis Abbreviations: MPM: malignant pleural mesothelioma; CI: confidence interval; HR: hazard ratio Received: November 30, 2016     Accepted: April 10, 2017     Published: April 26, 2017 ABSTRACT Background: Soluble mesothelin is beneficial to detect the progression and the treatment response of malignant pleural mesothelioma. However, the prognostic value of soluble mesothelin in malignant pleural mesothelioma remains unclear. Methods: Hazard ratio with 95% CI was used to evaluate the prognostic value of soluble mesothelin and the effect of clinicopathological characteristics on the survival of malignant pleural mesothelioma. Results: Eight eligible studies involving 579 patients were selected for this meta-analysis. The results showed that soluble mesothelin level was significantly correlated with the survival of malignant pleural mesothelioma (pooled HR: 1.958, 95%CI: 1.531-2.504, p = 0.000; heterogeneity test: I 2 = 1.1%, p = 0.421). In addition, the survival of malignant pleural mesothelioma was significantly correlated with some clinicopathological characteristics such as tumor histology (HR = 3.214, 95% CI = 2.071-4.988, p = 0.000; heterogeneity test: I 2 = 0.0%, p = 0.623) and tumor stage (HR = 2.007; 95% CI = 1.477-2.727; p = 0.000; heterogeneity test: I 2 = 0.0%, p = 0.966). Conclusions: The survival of malignant pleural mesothelioma is significantly correlated with tumor histology and tumor stage. Furthermore, high soluble mesothelin level may lead to a poor prognosis for malignant pleural mesothelioma patients.

Prognostic significance of soluble mesothelin in malignant pleural mesothelioma: a meta-analysis.

Patterns of care and survival among patients with malignant mesothelioma in the United States.

Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey

/pdf/prognostic-factors-in-elderly-patients-with-malignant-1hbt8zn8dl.pdf

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Prognostic factors in elderly patients with malignant pleural mesothelioma: results of a multicenter survey