D. De Valck
Ghent University
7 Papers
282 Citations
D. De Valck is an academic researcher from Ghent University. The author has contributed to research in topics: Tumor necrosis factor alpha & Apoptosis. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of D. De Valck include Laboratory of Molecular Biology.
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Papers
•Journal Article
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Bart Vanhaesebroeck,J. C. Reed,D. De Valck,J. Grooten,T. Miyashita,S. Tanaka,Rudi Beyaert,F. Van Roy,Walter Fiers +8 more
TL;DR: Data establish the absence of a correlation between bcl-2 gene expression and cellular sensitivity to TNF-induced cell lysis, a cytokine capable of inducing apoptosis in several tumor cell lines.
115
•Journal Article
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis
Walter Fiers,Rudi Beyaert,Elke Boone,Sigrid Cornelis,Wim Declercq,Els Decoster,Geertrui Denecker,B Depuydt,D. De Valck,G. De Wilde,V. Goossens,J. Grooten,Guy Haegeman,Karen Heyninck,Louis C. Penning,Stéphane Plaisance,Katia Vancompernolle,W. Van Criekinge,Peter Vandenabeele,W. Vanden Berghe,M. Van De Craen,Veronique Vandevoorde,Dominique Vercammen +22 more
TL;DR: In the mouse, seven cysteine proteases of the IHO family have been cloned and partially characterized and one substrate, which may be a key effector molecule in the apoptotic process, is PITSLRE kinase.
109
•Journal Article
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
TL;DR: Evidence is provided that TNF cytotoxicity and its enhancement by LiCl are mediated by increased IPn accumulation resulting in Ca2+ mobilization.
36
•Journal Article
Sensitization of Tumor Cells to Tumor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine
Rudi Beyaert,Bart Vanhaesebroeck,Karen Heyninck,Elke Boone,D. De Valck,Klaus Schulze-Osthoff,Guy Haegeman,F. Van Roy,Walter Fiers +8 more
TL;DR: It is reported that the protein kinase inhibitor staurosporine increases about 500 times the in vitro cytotoxic activity of TNF for several murine and human tumor cell lines, suggesting that TNF responsiveness of tumor cells is regulated by a novel stauosporine-sensitive target and that the combination of T NF and stauOSporine may open new strategies of tumor treatment.
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Tumor Necrosis Factor: Mechanism of Action at the Molecular, Cellular and in vivo Level
Walter Fiers,Rudi Beyaert,Peter Brouckaert,Els Decoster,D. De Valck,Bart Everaerdt,J. Grooten,A. Lenaerts,Claude Libert,Klaus Schulze-Osthoff,N. Takahashi,Jan Tavernier,S. Van Bladel,C. Van Dorpe,Bart Vanhaesebroeck,X. Van Ostade,F. Van Roy +16 more
- 01 Jul 1992
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