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Lehninger Principles Of Biochemistry 5th Edition

Nature Reviews Cancer

Objective— Diurnal variations in levels of factor VII (FVII), FVIII, proteins C and S, antithrombin, plasminogen activator inhibitor-1, prothrombin fragment F1+2, and D-dimers in healthy humans point to the existence of circadian rhythms of coagulation factors. We sought for temporal fluctuations of tissue factor pathway inhibitor (TFPI) activity in human and mouse plasma. Methods and Results— TFPI activity showed significant daily variations with highest levels in the morning in healthy men (+11%) and in mice at the light-to-dark transition (+63%), the beginning of the physically active period. Variations in FVII activity paralleled those in TFPI. In mice, the feeding schedule had a strong impact on these rhythms. Although restricted feeding and fasting shifted the peak of TFPI, the FVII peak disappeared. Investigation of temporal fluctuations in constant darkness indicated the existence of daily rhythms for TFPI and of true circadian rhythms for FVII. Conclusions— For the first time, we report, both in ...

Daily and Circadian Rhythms of Tissue Factor Pathway Inhibitor and Factor VII Activity

The projec developed in collaboration with Professor D.Mari, Ospedale Maggiore Policlinico of Milan, the expert advice on anticoagulation in elderly

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Network Based Simulation on HPC for Translational Medicine: an Application to Anticoagulation

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Network Based Simulation on HPC for Translational Medicine: an Application to Anticoagulation