5 Papers
82 Citations
D. Caput is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Interleukin 13 & Interleukin 1 receptor antagonist. The author has an hindex of 5, co-authored 5 publications.
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Papers
Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15.
DJ Matthews,P A Clark,J. Herbert,Gareth Morgan,Richard J. Armitage,Christine Kinnon,A Minty,KH Grabstein,D. Caput,P Ferrara +9 more
TL;DR: B cells from two X-SCID patients with characterized gamma c-chain gene mutations do not respond to IL-2 or IL-15, but respond as well or better than normal B cells to both IL-4 and IL-13 in assays for B-cell activation, proliferation, and IgE secretion.
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Regulation of endothelial and mesothelial cell function by interleukin-13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production.
Marina Sironi,Francesca L. Sciacca,Cristian Matteucci,M. Conni,Annunciata Vecchi,Sergio Bernasconi,A Minty,D. Caput,P Ferrara,Francesco Colotta +9 more
TL;DR: IL-13 elicits a spectrum of responses in vascular endothelium remarkably similar to that of IL-4 and IL-10, which may play an important role in the induction and expression of Th2-dependent responses.
123
Interleukin-13 induces expression and release of interleukin-1 decoy receptor in human polymorphonuclear cells.
Francesco Colotta,Fabio Re,Marta Muzio,Nadia Polentarutti,A Minty,D. Caput,P Ferrara,Alberto Mantovani +7 more
TL;DR: Results show that PMN is an important target for IL-13 and that induction of expression and release of the IL-1 decoy R, in concert with inhibition of cytokine synthesis, may represent an important mechanism by whichIL-13 blocks IL- 1, a central mediator of inflammatory reactions.
85
Interleukin-13 induces the production of interleukin-1 receptor antagonist (IL-1RA) and the expression of the mRNA for the intracellular (keratinocyte) form of IL-1RA in human myelomonocytic cells
Nadia Polentarutti,Marta Muzio,Marina Sironi,A Minty,D. Caput,P Ferrara,A. Mantovani,Francesco Colotta +7 more
TL;DR: IL-13 induced production of IL-1ra in myelomonocytic cells, augmenting both cell-associated and released protein, and may represent a further mechanism by which this molecule can counteract the potent proinflammatory properties ofIL-1.
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Interleukin-13 induces the production of interleukin-1 receptor antagonist (IL-1ra) and the expression of the mRNA for the intracellular (keratinocyte) form of IL-1ra in human myelomonocytic cells
Marta Muzio,Fabio Re,Marina Sironi,Nadia Polentarutti,A Minty,D. Caput,P Ferrara,Alberto Mantovani,Francesco Colotta +8 more
TL;DR: IL-13 induced production of IL- 1ra in myelomonocytic cells, augmenting both cell-associated and released protein, and may represent a further mechanism by which this molecule can counteract the potent proinflammatory properties ofIL-1.