D. B. Lowrie
National Institute for Medical Research
8 Papers
81 Citations
D. B. Lowrie is an academic researcher from National Institute for Medical Research. The author has contributed to research in topics: Mycobacterium microti & Vaccination. The author has an hindex of 7, co-authored 8 publications.
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Papers
Is macrophage death on the field of battle essential to victory, or a tactical weakness in immunity against tuberculosis?
TL;DR: A different concept is also gaining ground, that active destruction of cytotoxic cells in the immune response to infected macrophages containing mycobacteria may be of positive benefit and even crucial to the expression of protective immunity against tuberculosis and leprosy.
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Monocyte antimycobacterial activity before and after Mycobacterium bovis BCG vaccination in Chingleput, India, and London, United Kingdom.
Shuk Han Cheng,K B Walker,D. B. Lowrie,D. A. Mitchison,Raji Swamy,Manjula Datta,R. Prabhakar +6 more
TL;DR: This paper found that mycobacterium bovis BCG vaccination did not enhance bacteriostasis with the Indians but did so with the Londoners, and no evidence was found for involvement of cytokines such as macrophage-activating factor and granulocyte macrophages colony-stimulating factor in the differences.
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•Journal Article
Demonstration of increased anti-mycobacterial activity in peripheral blood monocytes after BCG vaccination in British school children.
TL;DR: Growth rates in lymphocyte-pulsed monolayers were significantly lower after vaccination than before, and it is proposed that this difference reflects the protective effect of vaccination.
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The pattern of mycobacterial antigen recognition in sera from Mantoux-negative individuals is essentially unaffected by bacille Calmette-Guérin (BCG) vaccination in either south India or London.
S. Das,Shuk Han Cheng,D. B. Lowrie,K B Walker,D. A. Mitchison,R. S. Vallishayee,P. R. Narayanan +6 more
TL;DR: Western blotting showed that even before vaccination, and even in British subjects, antibodies were present that recognized numerous antigenic components in extracts of BCG and M. tuberculosis, and there was no consistent difference between band patterns with South Indian and British subjects.
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Human Tuberculosis Sera Show Prominent Antibody Responses to Particulate Fractions of Mycobacterium tuberculosis
TL;DR: Sera from smear-positive pulmonary tuberculosis patients and normal control subjects in Madras were analyzed by Western blotting for their reactivity with soluble and particulate antigen fractions extracted by sonication from Mycobacterium tuberculosis H37Rv, suggesting that a serodiagnostic test might be based on quantitation of responses to these two antigens.
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