Cyrille Deboux
Pierre-and-Marie-Curie University
19 Papers
106 Citations
Cyrille Deboux is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Myelin & Biology. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Cyrille Deboux include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Papers
Molecular mechanism of systemic delivery of neural precursor cells to the brain: assembly of brain endothelial apical cups and control of transmigration by CD44.
Christine Rampon,Christine Rampon,Christine Rampon,Nicolas Weiss,Nicolas Weiss,Nicolas Weiss,Cyrille Deboux,Cyrille Deboux,Nathalie Chaverot,Nathalie Chaverot,Nathalie Chaverot,Florence Miller,Florence Miller,Florence Miller,Delphine Buchet,Delphine Buchet,Hélène Tricoire‐Leignel,Hélène Tricoire‐Leignel,Hélène Tricoire‐Leignel,Sylvie Cazaubon,Sylvie Cazaubon,Sylvie Cazaubon,Anne Baron-Van Evercooren,Anne Baron-Van Evercooren,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Pierre-Olivier Couraud +26 more
TL;DR: It is shown that soluble hyaluronic acid, the major ligand of the adhesion molecule CD44, as well as anti‐CD44 blocking antibodies, largely prevents NPC adhesion to and migration across brain endothelium in inflammatory conditions.
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IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells
Nicolas Weiss,Nicolas Weiss,Cyrille Deboux,Cyrille Deboux,Nathalie Chaverot,Nathalie Chaverot,Florence Miller,Florence Miller,Anne Baron-Van Evercooren,Anne Baron-Van Evercooren,Pierre-Olivier Couraud,Pierre-Olivier Couraud,Sylvie Cazaubon,Sylvie Cazaubon +13 more
TL;DR: It is shown that human NPCs express receptors of the chemokines IL8 and CXCL13 and migrate across brain endothelial cells in vitro, in response to these chemokine, suggesting that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.
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Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
Céline Caillava,Renaud Vandenbosch,Beata Jablonska,Cyrille Deboux,Giulia Spigoni,Vittorio Gallo,Brigitte Malgrange,Anne Baron-Van Evercooren +7 more
TL;DR: Cdk2 is not essential for oligodendrocyte maturation and myelination during development, but in response to demyelination, its loss accelerates OPC differentiation and remyelinated.
Directing human neural stem/precursor cells into oligodendrocytes by overexpression of Olig2 transcription factor
Cecile L. Maire,Delphine Buchet,Delphine Buchet,Delphine Buchet,Christophe Kerninon,Christophe Kerninon,Christophe Kerninon,Cyrille Deboux,Cyrille Deboux,Cyrille Deboux,Anne Baron-Van Evercooren,Brahim Nait-Oumesmar +11 more
TL;DR: It is reported that transduction of hNPC with Olig2‐encoding lentiviral vectors enhances their commitment toward an oligodendroglial fate, and indicates that bHLH transcription factors, such as Olig1, are interesting targets for directing hN PC into myelinating oligod endodendrocytes.
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Adult DRG Stem/Progenitor Cells Generate Pericytes in the Presence of Central Nervous System (CNS) Developmental Cues, and Schwann Cells in Response to CNS Demyelination
Marie Vidal,Madlyne Maniglier,Cyrille Deboux,Corinne Bachelin,Violetta Zujovic,Anne Baron-Van Evercooren +5 more
TL;DR: It is demonstrated that adult DRG‐NPCs have quasi unlimited self‐expansion capacities without compromising their tissue specific molecular signature, and their dual responsiveness to developmental and lesion cues highlights their impressive adaptive and repair potentials making them valuable targets for regenerative medicine.
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