Cynthia Read
Butler Hospital
5 Papers
7 Citations
Cynthia Read is an academic researcher from Butler Hospital. The author has contributed to research in topics: Genetic architecture & Genome-wide association study. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Cynthia Read include Brown University.
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Papers
Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.
TL;DR: While extensive pMIN findings may reflect gene size bias, the extent and significance of PROP and TPM findings suggest that common variation at ion channel genes may capture some of the heritability of schizophrenia.
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Gene ontology analysis of pairwise genetic associations in two genome-wide studies of sporadic ALS.
Nora Chung Kim,Peter C. Andrews,Folkert W. Asselbergs,H. Robert Frost,Scott M. Williams,Brent T. Harris,Cynthia Read,Kathleen D. Askland,Jason H. Moore,Jason H. Moore +9 more
TL;DR: Pathway analysis of pairwise genetic associations in two GWAS of sporadic ALS revealed a set of genes involved in cellular component organization and actin cytoskeleton that were not reported by prior GWAS, suggesting that pathway-level analysis of GWAS data may discover important associations not revealed using conventional one-SNP-at-a-time approaches.
Psychiatric Neurosurgery 2009: Review and Perspective
TL;DR: Treatment using psychiatric neurosurgical procedures is further complicated by issues involving the criteria for patient selection, the long-term management of patients receiving psychiatric neurosurgery, and the different patterns of potential clinical benefits and burdens presented by DBS and contemporary lesion procedures.
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Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design.
Nicole C.R. McLaughlin,Nicole C.R. McLaughlin,Darin D. Dougherty,Emad N. Eskandar,Herbert E. Ward,Kelly D. Foote,Donald A. Malone,Andre G. Machado,William Wong,Mark Sedrak,Wayne K. Goodman,Brian H. Kopell,Fuad Issa,Donald C. Shields,Osama A. Abulseoud,Kendall H. Lee,Mark A. Frye,Alik S. Widge,Alik S. Widge,Thilo Deckersbach,Michael S. Okun,Dawn Bowers,Russell M. Bauer,Dana M. Mason,Cynthia S. Kubu,Ivan Bernstein,Kyle A.B. Lapidus,David L. Rosenthal,Robert L. Jenkins,Cynthia Read,Paul Malloy,Paul Malloy,Stephen Salloway,Stephen Salloway,David R. Strong,Richard N. Jones,Steven A. Rasmussen,Steven A. Rasmussen,Benjamin D. Greenberg,Benjamin D. Greenberg,Benjamin D. Greenberg +40 more
TL;DR: The study was conducted over a six-year period and was a NIH-funded, eight-center sham-controlled trial of DBS targeting the ventral capsule/ventral striatum (VC/VS) region.
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Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission
TL;DR: A series of PBAs conducted using exploratory visual analysis, an analytic and visualization software tool for examining genomic data, to examine results from the National Institutes of Mental Health and Wellcome-Trust Case Control Consortium WGAS in bipolar disorder suggest involvement of ion channel structural and regulatory genes, including voltage-gated ion channels and the broader ion channel group that comprises both voltage- and ligand- gated channels.