A facile strategy has been developed for the preparation of novel silver/poly(styrene-N-isopropylacrylamide-methacrylic acid) (Ag/PSNM) nanocomposite spheres with high catalytic activity and good storage stability. Silver (Ag) nanoparticles are successfully deposited on poly(styrene-N-isopropylacrylamide-methacrylic acid) (PSNM) spheres surfaces via in situ reduction and simultaneously protected by polyvinylpyrrolidone (PVP). The prepared Ag/PSNM nanocomposite spheres show good temperature/pH responsive property and improved thermal property. Moreover, they also exhibit high catalytic activity and good recyclability for the catalytic reduction of methylene blue (MB) to leuco methylene blue (LMB). The result of clock reaction indicate that the redox reaction generates a colorless (LMB) solution which easily reverts back to blue (MB) in air. The catalytic activity increase with the increasing of temperature and the reaction rate constant (k) follows the typical Arrhenius-type dependence on temperature. In addition, the prepared Ag/PSNM nanocomposite spheres show good storage stability and the catalytic activity remains almost unchanged after storage for 90 days at room temperature. Therefore, the prepared Ag/PSNM nanocomposite spheres can have a highly potential use in the catalytic degradation of organic dyes in wastewater treatment applications.

In-situ construction of novel silver nanoparticle decorated polymeric spheres as highly active and stable catalysts for reduction of methylene blue dye

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors.

Gadolinium-based contrast agents are extensively used as magnetic resonance imaging (MRI) contrast agents due to their outstanding signal enhancement and ease of chemical modification. However, it is increasingly recognized that information obtained from single modal molecular imaging cannot satisfy the higher requirements on the efficiency and accuracy for clinical diagnosis and medical research, due to its limitation and default rooted in single molecular imaging technique itself. To compensate for the deficiencies of single function magnetic resonance imaging contrast agents, the combination of multi-modality imaging has turned to be the research hotpot in recent years. This review presents an overview on the recent developments of the functionalization of gadolinium-based contrast agents, and their application in biomedicine applications.

The evolution of gadolinium based contrast agents: from single-modality to multi-modality

Integrating biomedical imaging and multimodal therapies into one platform for enhanced anticancer efficacy is of great significance. Herein, a core/shell structured nanotheranostic (CuS@copolymer) for magnetic resonance imaging (MRI)-guided chemo-photothermal therapy was simply prepared via emulsifier-free emulsion polymerization with the full participation of hydrophilic CuS NPs, styrene (St), N-isopropylacrylamide (NIPAm), methacrylic acid (MAA), and polymerizable rare earth complex (Gd(AA)3phen). The synthesized multifunctional microspheres with excellent biocompatibility exhibited high loading capacity (15.3 wt %) for DOX·HCl and excellent drug release under low pH and high temperature. The photosensitive CuS cores which can simultaneously efficiently absorb near-infrared (NIR) light and convert NIR light to fatal heat, leading to a synergistic therapeutic effect combined photothermal therapy (PTT) with chemotherapy. Moreover, the temperature sensitive copolymer attached onto the CuS nanoparticles was...

Dual-Stimuli-Responsive, Polymer-Microsphere-Encapsulated CuS Nanoparticles for Magnetic Resonance Imaging Guided Synergistic Chemo-Photothermal Therapy.

Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both 1H and 19F MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.

Activatable probes for diagnosis and biomarker detection by MRI

Smart polymer-based theranostic agents often have the problem of a low drug release rate and it is difficult for them to reach the site of brain tumors for magnetic resonance imaging (MRI). To synthesize a theranostic agent for brain tumor MRI with a high drug release rate, paramagnetic, pH and temperature-sensitive polymeric particles (PPPs) are synthesized using a simplified processes in this work. These dually sensitive polymeric particles show negligible cytotoxicity against HeLa and glioma (C6) cells. The obtained polymeric particles can effectively be loaded with the anticancer drug doxorubicin (DOX). In vitro drug release measurements exhibit retarded release profiles when subjected to varying pH or temperature. Moreover, DOX-loaded PPPs exhibit obvious antitumor properties for C6 cells. The percentage of cumulative DOX release is higher than 95% when both pH and temperature are changed. The T1-weighted relaxivity values at 3 T are 12.41 mM−1 s−1 (pH = 6.3) and 10.75 mM−1 s−1 (pH = 7.4). In vivo MRI reveals that the PPPs can be effectively imaged in brain tumors (gliomas). These results indicate that the PPPs have great potential in diagnosing and treating glioma.

Paramagnetic, pH and temperature-sensitive polymeric particles for anticancer drug delivery and brain tumor magnetic resonance imaging

The invention belongs to the field of material surface and inorganic porous material and specifically relates to a superhydrophobic coating and its preparation method. The preparation method comprises the following steps: a, adding 1-5 parts by weight of natural zeolite into 50-100 parts by weight of ethanol, carrying out ultrasonic dispersion for 10-30 min, adding 0.15-0.85 part by weight of perfluorodecyltrichlorosilane, and continuously carrying out ultrasonic dispersion for 10-30 min to obtain a dispersion liquid; b, immersing a base material into the dispersion liquid obtained in the step a for 3-5 min, taking out the base material and drying the base material at 50-70 DEG C for more than 30 min; and c, repeating the step b for two to three times so as to form the superhydrophobic coating on the surface of the base material. Natural zeolite belongs to an inorganic porous material and is easy to form a micro-nano structure in the coating. Meanwhile, there exist many hydroxide radicals on the surface of zeolite, and its surface energy is reduced after condensation between perfluorodecyltrichlorosilane and hydroxide radicals. Thus, the superhydrophobic effect is achieved. The natural zeolite is cheap and easily available. The preparation method is simple and easy for industrialization. The coating of the invention has a self-cleaning ability, is applicable to many base materials and is widely applied.

Superhydrophobic coating and preparation method thereof

The invention discloses a double-bond containing water-soluble gadolinium complex as well as a synthesis method and application thereof The double-bond containing water-soluble gadolinium complex contains an unsaturated carboxylic acid, stabilizer molecules and water molecules, wherein the unsaturated carboxylic acid serves as a ligand to ensure that the double-bond containing water-soluble gadolinium complex can participate in high-molecule polymerization, and the stabilizer molecules can improve the stability of the double-bond containing water-soluble gadolinium complex The imaging principle of an imaging agent reveals that the structure of the double-bond containing water-soluble gadolinium complex contains water molecules so that the double-bond containing water-soluble gadolinium complex can be improved in relaxation rate when used as an MRI (magnetic resonance imaging) agent The double-bond containing water-soluble gadolinium complex can be used as an excellent raw material for synthesizing an MRI agent with a high relaxation rate, and more importantly, due to the water solubility, the double-bond containing water-soluble gadolinium complex has great advantages when used as a raw material for synthesizing an MRI agent The invention further discloses the synthesis method of the double-bond containing water-soluble gadolinium complex The synthesis method of the double-bond containing water-soluble gadolinium complex is easy to operate, is friendly to environment and is low in cost, and the synthesized double-bond containing water-soluble gadolinium complex is easy to purify

Double-bond containing water-soluble gadolinium complex as well as synthesis method and application thereof

Smart polymeric particles possessing the advantages of paramagnetism, luminescence, and controlled drug delivery in a single entity are reported. Gadolinium oxide and europium-encapsulated temperature/pH-responsive polymeric particles (PLTPPs) synthesized by emulsifier-free emulsion polymerization show good biocompatibility with C6 cells and anticancer drug (doxorubicin, DOX) loading capability. In vitro drug release assessment discloses release abatement under acidic conditions or at high temperature, and the DOX-loaded PLTPPs have obvious antitumor properties for C6 and H22 cells. Cellular uptake tests confirm that the materials can be taken up by C6 cells thereby facilitating optical imaging. The T1-weighted relaxivity value at 3 T is 6.13 mM−1 s−1 which is 39% higher than that of the clinical Magnevist®. In vivo MR and optical imaging reveal that the PLTPPs are effective dual probes. The results indicate that the PLTPPs have great potential in tumor diagnosis and treatment.

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery

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Paramagnetic, pH and temperature-sensitive polymeric particles for anticancer drug delivery and brain tumor magnetic resonance imaging

Superhydrophobic coating and preparation method thereof

Double-bond containing water-soluble gadolinium complex as well as synthesis method and application thereof

Smart polymeric particle encapsulated gadolinium oxide and europium: theranostic probes for magnetic resonance/optical imaging and antitumor drug delivery