Cuixian Li
Southern Medical University
8 Papers
16 Citations
Cuixian Li is an academic researcher from Southern Medical University. The author has contributed to research in topics: Cochlea & Prestin. The author has an hindex of 4, co-authored 7 publications.
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Papers
Sequential Ultrasound-Triggered and Hypoxia-Sensitive Nanoprodrug for Cascade Amplification of Sonochemotherapy.
Fan Zhuang,Qiong Ma,Caihong Dong,Huijing Xiang,Yujia Shen,Pei Sun,Cuixian Li,Yi-xin Chen,Bei-li Lu,Yu Chen,Bei-jian Huang +10 more
TL;DR: This work provides a distinctive insight into the exploitation of the hypoxia-activated sonochemotherapeutic nanoprodrug that utilizes the hypoxic condition in TME, a side effect of SDT, to initiate chemotherapy, thus causing a significantly augmented treatment outcome compared to conventional SDT.
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Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats.
TL;DR: The present study suggests that the onset time of hearing may require the expression of prestin and is determined by the mature function of OHCs and that prestin expression synchronized with the hearing development.
Low-Intensity Ultrasound Causes Direct Excitation of Auditory Cortical Neurons.
Xiaofei Qi,Kexin Lyu,Long Meng,Cuixian Li,Hongzheng Zhang,Lili Niu,Zhengrong Lin,Hairong Zheng,Jie Tang +8 more
TL;DR: In this paper, low-intensity ultrasound (US) was employed to stimulate auditory cortical neurons in vitro to elicit the inward current and action potentials in cultured neurons c-Fos staining results indicate that low intensity US is efficient for stimulating most neurons, implying that US-induced neural modulation can be a potential approach for activating the auditory cortex of deaf patients.
Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats.
TL;DR: A step-by-step protocol to study the function of OHCs in acutely dissociated cochlea from postnatal rats is described, which can evaluate the cochlear response to pure tone stimuli and examine the expression level and function of the motor protein prestin in O HCs.
Patent
Application of mTOR signal path inhibitor to preparation of medicament for preventing or treating extragenetic hearing impairment
Jie Tang,Cuixian Li,Shasha Guo +2 more
- 24 Jul 2018
TL;DR: The mTOR signal path inhibitor can effectively relieve damage to inner ear hair cells and spiral ganglion cells caused by non-genetic factors such as ototoxic drug, remarkably improve the impaired listening ability, and effectively prevent and treat extragenetic hearing impairment.