The invention relates to a monodispersed fluorescent magnetic nanometer probe and the preparation and application thereof. The magnetic nanometer probe consists of Fe304 magnetic nanometer particles of load photosensitizer, target molecules modified by PEG and hyperbranched polymer NPO; Molar ratio of Fe304 magnetic nanometer particles of load photosensitizer, target molecules modified by PEG and hyperbranched polymer NPO is (0.0005-1):(1-10):(0.5-2); Fe304 magnetic nanometer particles of load photosensitizer consist of photosensitizer and Fe304 carrier; mass ratio of the photosensitizer and Fe304 carrier is (1-5):(4-20); The nanometer probe is made through the solvothermal method and can be used for making the imaging agent of targeted imaging of cancer cells or drugs for targeted treatment of cancers. Compared with the prior art, the invention has the strengths of simple preparation techniques, high efficiency of targeted treatment, good biologic compatibility, and can improve the efficacy and increase the surface size effect of hydrophobic antineoplastic drugs, and strengthen imaging and treatment.

Monodispersed fluorescent magnetic nanometer probe and the preparation and application thereof

The invention relates to a targeted superparamagnetic monodisperse nano-flower probe, the preparation and the application thereof. A nano-flower probe is composed of three parts, namely a magnetic gold-bearing particle nano-flower, a hyperbranched macromolecular HPG and a target molecule, wherein one end of the hyperbranched macromolecular HPG is provided with a mercapto group and a branched terminal. The nano-flower probe is prepared through the hot solvent method. That is, firstly, a Fe3O4 carrier is prepared. Secondly, a golden seed is loaded on the carrier, and then the magnetic gold-bearing particle nano-flower is obtained. Finally, the magnetic gold-bearing particle nano-flower is connected sequentially with the HPG and the target molecule. The above nano-probe is applied to the oncotherapy for animal in-vivo double-targeted imaging under the alternating magnetic field. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe is simple to prepare, low in cost, high in targeting efficiency, and small in oncotherapy side effect. Compared with the prior art, the targeted superparamagnetic monodisperse nano-flower probe has the advantages of simple preparation, low cost, high targeting efficiency, small oncotherapy side effect and the like.

Targeted superparamagnetic monodisperse nano-flower probe, preparation and application thereof

The invention discloses a polycaprolactone hybrid cross-linked network with a thermal/magnetic response two-way shape memory function and self-healing capability and a preparation method of the polycaprolactone hybrid cross-linked network. A structural formula of a polymer part of the polycaprolactone hybrid cross-linked network is as shown in the specification. In the formula, PCL represents a polycaprolactone chain segment with a number-average molecular weight of 2000-10000g/mol; and R represents a hydrocarbonyl part in a coupling agent diisocyanate. The polycaprolactone hybrid cross-linked network is a novel semi-crystalline polycaprolactone hybrid cross-linked network with the advantages of two-way shape memory function, thermal/magnetic response, reprocessibility, self-healing capability and the like. According to the preparation method, catechol group terminated polycaprolactone and Fe3O4 nano-particles are subjected to coordination crosslinking. The preparation method comprises the following specific steps: 1) preparing the catechol group terminated polycaprolactone; 2) preparing oleic acid group modified Fe3O4 nano-particles; and 3) preparing the polycaprolactone hybrid cross-linked network.

Polycaprolactone hybrid cross-linked network with thermal/magnetic response two-way shape memory function and self-healing capability and preparation method of polycaprolactone hybrid cross-linked network

The invention relates to a multifunctional Cu3BiS3-PEG-(Ce6-Gd )-FA nano composite material, and a preparation method and application thereof. The preparation method comprises the following steps: preparing oil-soluble Cu3BiS3 nanoparticles by using as Bi(DEDC)3 and Cu(DEDC)2 precursors, sequentially preparing DSPE-PEG/DSPE-PEG-NH2-modified water-soluble Cu3BiS3 nanoparticles, a Cu3BiS3-PEG-Ce6 water solution and a Cu3BiS3-PEG-(Ce6-Gd ) water solution, and finally, coupling FA to the Cu3BiS3-PEG-(Ce6-Gd ) to prepare the multifunctional Cu3BiS3-PEG-(Ce6-Gd )-FA nano composite material. The composite material is used for preparing CT (computerized tomography) contrast agents, MRI (magnatic resonance imaging) contrast agents, photothermal converters or photosensitive drugs. Compared with the prior art, the composite material can integrate photothermal and photodynamic treatment means to implement photothermal/photodynamic synergic treatment on cancers, and can also be used as MRI and CT contrast agents to implement bimodal imaging. The research on multiple molecule image probes on one molecule indicates that the composite material has wide application prospects in the field of biomedicine.

Multifunctional Cu3BiS3-PEG-(Ce6-Gd )-FA nano composite material, and preparation method and application thereof

The invention discloses a synthesis method of a FeS2 composite positive electrode material, and a battery. The method comprises the following steps: dispersing a ferrous salt of an organic acid, thiourea, PVP and a chelating agent in a solvent, carrying out a polymerization reaction to form sol, further generating gel, carrying out heat treatment and grinding to prepare FeS2 powder, adding metal powder with the mass percentage of 0.1-2%, and carrying out surface coating in order to obtain the FeS2 composite positive electrode material. The battery comprises the composite positive electrode material synthesized through the method. The synthesized composite positive electrode material has the characteristics of high purity, small particle size, fast ion diffusion rate and high specific capacity, and effectively controls the open circuit voltage of the produced battery to be lower than 1.83 V; and the metal powder is used to coat iron disulfide, so the electric conductivity of the positive electrode material is enhanced, the rate performances are improved, the erosion of an electrolyte to the material is alleviated, the life of the battery is prolonged, and the discharge performance of the battery at a heavy current is effectively improved.

Synthesis method of FeS2 composite positive electrode material, and battery

The invention relates to a hyperstable monodisperse fluorescent magnetic nano probe and preparation and application thereof. The fluorescent magnetic nano probe comprises a carrier and a light-sensitive agent, wherein the carrier is composed of carboxylated ferriferrous oxide magnetic nano particles, PEG and target molecules, and the light-sensitive agent is loaded on the carrier. The preparation method includes the specific steps that firstly, ascorbic acid is placed in an ferric salt solution, the pH value of the solution is adjusted to be 9-12, stirring and hydrothermal reaction are conducted, and an MNPs-COOH dispersion solution is obtained; secondly, the MNPs-COOH dispersion solution is centrifuged, then carboxyl groups of the MNPs-COOH dispersion solution are activated, PEG is added, mixing reaction is conducted, and an MNPs-PEG dispersion solution is obtained; thirdly, activated target molecules are added into and mixed with the MNPs-PEG dispersion solution for reaction, and an MNPs-PEG dispersion solution with the target molecules is obtained; fourthly, the MNPs-PEG dispersion solution with the target molecules and the light-sensitive agent solution are stirred and mixed and react, and a target product is obtained. The nano probe is used for dual-mode tomography in animal bodies. Compared with the prior art, the hyperstable monodisperse fluorescent magnetic nano probe has the advantages that targeting efficiency is high, residence time on tumor portions is long, and the preparation technology is simple.

Hyperstable monodisperse fluorescent magnetic nano probe and preparation and application thereof

The invention provides a preparation method of a targeted superparamagnetic nano-probe. The method includes the steps of: 1. preparing ferroferric oxide nano-particles with a particle size of 10-20nm in an oil phase by high temperature thermal decomposition; 2. synthesizing an amphiphilic polymer; 3. conducting aqueous phase transformation of the ferroferric oxide nano-particles obtained by step 1 through the amphiphilic polymer obtained by step 2 so as to obtain water-soluble superparamagnetic nano-particles; and 4. under the coupling effect of EDC/NHS, subjecting the water-soluble superparamagnetic nano-particles obtained by step 3 to covalent coupling with a target molecule, thus obtaining the targeted superparamagnetic nano-probe. The invention also provides an application method of the probe. Under the action of a separation column and an applied magnetic field, the probe can specifically and effectively capture and separate target cells. Compared with the prior art, the probe prepared by the method provided by the invention has the advantages of uniform particle size, high T2 relaxation rate, good stability, high pH value, high salt tolerance, and good target cell separation effect.

Preparation method and application method of targeted superparamagnetic nano-probe

The invention relates to ferrous disulfide microspheres and a preparation method thereof. The ferrous disulfide microspheres are microspheres with single hole structures and are formed by clustering ferrous disulfide nano particles. The preparation method comprises the following steps: (1) dissolving ferric salt or ferrite into deionized water to obtain a solution; (2) adding thiourea into the solution, and carrying out stirring to dissolve the thiourea to obtain a mixed solution; (3) adding polyvinylpyrrolidone into the mixed solution, and carrying out ultrasonic stirring to obtain reaction liquid; (4) putting the reaction liquid into a reaction kettle, and after the reaction is completed, carrying out cooling, washing and centrifugating to obtain the ferrous disulfide microspheres. Compared with the prior art, the ferrous disulfide microspheres and the preparation method thereof which are disclosed by the invention have the advantages that the microspheres are uniform in particle size, the synthesis process is simple, a few of types of raw materials are needed, and the requirement on equipment is relatively low.

Ferrous disulfide microspheres and preparation method thereof

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Cui Daxiang

Author Tools

Chat about Author