Crystal Cabral
Beth Israel Deaconess Medical Center
11 Papers
21 Citations
Crystal Cabral is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Immune system & Simian immunodeficiency virus. The author has an hindex of 8, co-authored 9 publications.
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Papers
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
James B. Whitney,Alison L. Hill,Srisowmya Sanisetty,Pablo Penaloza-MacMaster,Jinyan Liu,Mayuri Shetty,Lily Parenteau,Crystal Cabral,Jennifer L. Shields,Stephen Blackmore,Jeffrey Y. Smith,Amanda L. Brinkman,Lauren Peter,Sheeba I. Mathew,Kaitlin M. Smith,Erica N. Borducchi,Daniel I. S. Rosenbloom,Mark G. Lewis,Jillian Hattersley,Bei Li,Joseph Hesselgesser,Romas Geleziunas,Merlin L. Robb,Jerome H. Kim,Nelson L. Michael,Dan H. Barouch +25 more
TL;DR: It is demonstrated that the viral reservoir is seeded rapidly after intrarectal SIV infection of rhesus monkeys, during the ‘eclipse’ phase, and before detectable viraemia, which raises important new challenges for HIV-1 eradication strategies.
Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Peter Abbink,Rafael A. Larocca,Rafael De La Barrera,Christine A. Bricault,Edward T. Moseley,Michael R. Boyd,Marinela Kirilova,Zhenfeng Li,David Ng’ang’a,Ovini Nanayakkara,Ramya Nityanandam,Noe B. Mercado,Erica N. Borducchi,Arshi Agarwal,Amanda L. Brinkman,Crystal Cabral,Abishek Chandrashekar,Patricia B. Giglio,David Jetton,Jessica Jimenez,Benjamin C. Lee,Shanell Mojta,Katherine Molloy,Mayuri Shetty,George H. Neubauer,Kathryn E. Stephenson,Jean Pierre Schatzmann Peron,Paolo Marinho de Andrade Zanotto,Johnathan Misamore,Brad Finneyfrock,Mark G. Lewis,Galit Alter,Kayvon Modjarrad,Richard G. Jarman,Kenneth H. Eckels,Nelson L. Michael,Stephen J. Thomas,Dan H. Barouch,Dan H. Barouch +38 more
TL;DR: It is demonstrated that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys, and these data support the rapid clinical development of ZikV vaccines for humans.
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Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys
Erica N. Borducchi,Crystal Cabral,Kathryn E. Stephenson,Jinyan Liu,Peter Abbink,David Ng’ang’a,Joseph P. Nkolola,Amanda L. Brinkman,Lauren Peter,Benjamin C. Lee,Jessica Jimenez,David Jetton,Jade Mondesir,Shanell Mojta,Abishek Chandrashekar,Katherine Molloy,Galit Alter,Jeffrey M. Gerold,Alison L. Hill,Mark G. Lewis,Maria G. Pau,Hanneke Schuitemaker,Joseph Hesselgesser,Romas Geleziunas,Jerome H. Kim,Merlin L. Robb,Nelson L. Michael,Dan H. Barouch,Dan H. Barouch +28 more
TL;DR: The combination of Ad26/MVA vaccination and TLR7 stimulation resulted in decreased levels of viral DNA in lymph nodes and peripheral blood, and improved virologic control and delayed viral rebound following discontinuation of antiretroviral therapy, demonstrating the potential of therapeutic vaccination combined with innate immune stimulation as a strategy aimed at a functional cure for HIV-1 infection.
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens.
Pablo Penaloza MacMaster,Jennifer L. Shields,Quazim A. Alayo,Crystal Cabral,Jessica Jimenez,Jade Mondesir,Abishek Chandrashekar,Joseph M Cabral,Matthew Lim,M. Justin Iampietro,Nicholas M. Provine,Christine A. Bricault,Michael S. Seaman,Klaus Orlinger,Andreas Aspoeck,Gerhard Fuhrmann,Anders Lilja,Thomas P. Monath,Bastien Mangeat,Daniel D. Pinschewer,Dan H. Barouch,Dan H. Barouch +21 more
TL;DR: Immunization with rLCMV vaccine vectors expressing SIV Env and Gag was effective at generating SIV-specific T cell and antibody responses in both mice and NHPs and suggests the potential of r LCMV vectors as vaccine candidates.
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Adenovirus Serotype 26 and 35 Vectors Induce Simian Immunodeficiency Virus-Specific T Lymphocyte Responses in Foreskin in Rhesus Monkeys
Emmanuel Balandya,Andrew D. Miller,Matthew Beck,Jinyan Liu,Hualin Li,Erica N. Borducchi,Kaitlin M. Smith,Crystal Cabral,Kelly Stanley,Lori F. Maxfield,Dan H. Barouch,Dan H. Barouch +11 more
TL;DR: Intramuscular immunization with adenovirus serotype 26 and 35 vectors expressing SIV antigens elicited durable SIV Gag-specific CD4+ and CD8+ T cell responses in foreskin that were detectable for more than 1 year following vaccination, suggesting that systemic vaccination strategies can elicit potentially important SIV-specific cellular immunity in foreskin.
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