Cristina Colombo
Vita-Salute San Raffaele University
226 Papers
1.9K Citations
Cristina Colombo is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Bipolar disorder & Mood disorders. The author has an hindex of 53, co-authored 211 publications. Previous affiliations of Cristina Colombo include University of Milan & Università telematica San Raffaele.
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Papers
Brain spectroscopic measures of glutamatergic and neuronal metabolism and glial activation influence white matter integrity in bipolar depression
B. Bravi,Irene Bollettini,C. D. Pasquasio,Andrea Falini,Cristina Colombo,Raffaella Zanardi,Sara Poletti,Francesco Benedetti +7 more
TL;DR: In this paper , the authors investigated brain concentrations of Glu, Glx, NAA, mI as indirect marker of microglia activation, and Glx/NAA ratio as index of neuronal damage through 1H-MR, and WM integrity with Tract-Based Spatial Statistics in 93 depressed BD patients and 58 healthy controls (HC).
Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders.
TL;DR: Investigation of the association between glutamate levels in the hippocampus, measured through single proton magnetic resonance spectroscopy (1H-MRS), and ACE in patients affected by mood disorders and healthy controls finds higher levels of early stress associate to reduced levels of Glx/Cr inThe hippocampus in depressed patients but not in healthy controls.
Opposite effects of suicidality and lithium on gray matter volumes in bipolar depression.
Francesco Benedetti,Daniele Radaelli,Sara Poletti,Sara Poletti,Clara Locatelli,Andrea Falini,Cristina Colombo,Enrico Smeraldi +7 more
TL;DR: Reduced GM volumes in critical cortical areas of suicidal patients could be a biological correlate of an impaired ability to associate choices and outcomes and to plan goal-directed behaviors based on a lifetime historical perspective, which, coupled with mood-congruent depressive cognitive distortions, could lead to more hopelessness and suicide.
Chronotype influences response to antidepressant chronotherapeutics in bipolar patients.
TL;DR: Patient diurnal mood fluctuation, sleep characteristics and factors affecting sleep homeostasis predict antidepressant response to the combination of total sleep deprivation and light therapy (TSD + LT).
Association between GSK-3β -50T/C polymorphism and personality and psychotic symptoms in mood disorders
Alessandro Serretti,Francesco Benedetti,Laura Mandelli,Raffaella Calati,Barbara Caneva,Cristina Lorenzi,Valentina Fontana,Cristina Colombo,Enrico Smeraldi +8 more
TL;DR: The findings support the role of GSK-3beta-50 in both normal and psychopathological aspects of human cognition and further suggest a possible interaction between genes and personality in the liability to psychotic disorders.