Cristiane Naffah de Souza Breda
University of São Paulo
11 Papers
28 Citations
Cristiane Naffah de Souza Breda is an academic researcher from University of São Paulo. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 5, co-authored 11 publications.
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Papers
Mitochondria as central hub of the immune system
Cristiane Naffah de Souza Breda,Gustavo Gastão Davanzo,Paulo José Basso,Niels Olsen Saraiva Câmara,Pedro M. Moraes-Vieira +4 more
TL;DR: The role of mitochondria on the development and function of immune cells is described, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondia that sustain cell function.
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The lack of PI3Kγ favors M1 macrophage polarization and does not prevent kidney diseases progression.
Mariane Tami Amano,Angela Castoldi,Vinicius Andrade-Oliveira,Marcela Teatin Latancia,Fernanda Fernandes Terra,Matheus Correa-Costa,Cristiane Naffah de Souza Breda,Raphael José Ferreira Felizardo,Welbert Oliveira Pereira,Marina Brito Silva,Mariana Miyagi,Cristhiane Favero Aguiar,Meire Ioshie Hiyane,João Santana da Silva,Ivan C. Moura,Niels Olsen Saraiva Camara +15 more
TL;DR: It is demonstrated that the lack of PI3K&ggr; favors M1 macrophages polarization providing an inflammatory‐prone environment, which does not prevent kidney diseases progression and promotes a more inflammatory environment.
21
Cholesterol-Ester Transfer Protein Alters M1 and M2 Macrophage Polarization and Worsens Experimental Elastase-Induced Pulmonary Emphysema.
Kelly Gomes Santana,Renato Fraga Righetti,Cristiane Naffah de Souza Breda,Omar Domínguez-Amorocho,Theresa Ramalho,Francisca Elda B Dantas,Valéria S. Nunes,Iolanda F.L.C. Tibério,Francisco Garcia Soriano,Niels Olsen Saraiva Câmara,Eder Carlos da Rocha Quintão,Patrícia M. Cazita +11 more
TL;DR: In this paper, the role of CETP in macrophage polarization and elastase-induced pulmonary emphysema (ELA) in human CETP-expressing transgenic (huCETP) male mice and compared it to their wild type littermates.
Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis.
Cristiane Naffah de Souza Breda,Leandro Carvalho Dantas Breda,Larissa Anastácio da Costa Carvalho,Mariane Tami Amano,Fernanda Fernandes Terra,Reinaldo Correia Silva,Matheus Garcia Fragas,Maria Fernanda Forni,Maria Fernanda Forni,Monique T. Fonseca,Gabriela Venturini,Amanda Campelo Melo Feitosa,Bruno Ghirotto,Mario Cruz,Flavia Franco da Cunha,Aline Ignacio,Marcela Teatin Latância,Angela Castoldi,Vinicius Andrade-Oliveira,Eloisa Martins da Silva,Meire Ioshie Hiyane,Alexandre C. Pereira,William T. Festuccia,Flavia Carla Meotti,Niels Olsen Saraiva Câmara +24 more
TL;DR: In this paper, the authors found that neutrophil microbicidal capacity was impaired in Rictor-deleted neutrophils because of an improper fusion of granules, reducing the hypochlorous acid production.
3
MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytes
Bruno Ghirotto,Danyllo Oliveira,Marcella Cipelli,Paulo José Basso,J. J. G. de Lima,Cristiane Naffah de Souza Breda,H. C. Ribeiro,C. C. C. Silva,Meire Ioshie Hiyane,Elia Garcia Caldini,Alessandra Sussulini,Alicia J. Kowaltowski,E. M. L. Oliveira,Mayana Zatz,Niels Olsen Saraiva Camara +14 more
TL;DR: In this article, the authors characterized induced pluripotent stem cell (iPSC)-derived astrocytes from patients with multiple sclerosis (PwMS), focusing mainly on mitochondrial function and cell metabolism.