Craig W. Lindsley
Vanderbilt University
911 Papers
4.7K Citations
Craig W. Lindsley is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Allosteric regulation & Metabotropic glutamate receptor. The author has an hindex of 74, co-authored 817 publications. Previous affiliations of Craig W. Lindsley include University of Michigan & Johnson & Johnson.
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Papers
Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
Aaron T. Garrison,Douglas L. Orsi,Rory A. Capstick,David Whomble,Jin-ming Li,Trever R. Carter,Andrew S. Felts,Paige N. Vinson,Allie Han,Krishma Hajari,Hyekyung P. Cho,Laura B. Teal,Madeline G. Ragland,Masoud Ghamari-Langroudi,Michael Bubser,Si-Jia Chang,Nathalie Schnetz-Boutaud,Olivier Boutaud,Anna L. Blobaum,Daniel J. Foster,Colleen M. Niswender,P. Jeffrey Conn,Craig W. Lindsley,Carrie K. Jones,Chang Hoo Han +24 more
TL;DR: In acute brain slice electrophysiology studies, VU6019650 (27b) blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area, a part of the mesolimbic dopaminergic reward circuitry.
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Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model.
Jessica V. Kaczmarek,Carley M. Bogan,Janene Pierce,Yuankai K. Tao,Sheau-Chiann Chen,Qi Liu,Xiao Liu,Kelli L. Boyd,M. Wade Calcutt,Thomas M. Bridges,Craig W. Lindsley,Debra L. Friedman,Ann Richmond,Anthony B. Daniels +13 more
TL;DR: In this paper, the authors systematically studied whether the HDAC inhibitor belinostat is a viable, molecularly targeted alternative agent for intravitreal delivery that might provide comparable efficacy, without toxicity.
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Progress toward the synthesis of piperazimycin A : exploration of the synthesis of γ-hydroxy and γ-chloropiperazic acids
TL;DR: In this paper, an expedient route to key (3 S,5 S )- and (3 R,5 R )-γ-hydroxy and ( 3 R, 5 S ) -γ-chloropiperazic acids, was developed en route to a total synthesis of piperazimycin A.
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A New Bromo Trienyne: Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics.
Bruce H. Lipshutz,Brett R. Ullman,Craig W. Lindsley,Sabina Pecchi,Daniel J. Buzard,David P. Dickson +5 more
TL;DR: Tanaka et al. as discussed by the authors described a redesigned tetraene equivalent, which provides synthetic opportunities not available to the original Pd(0)-catalyzed vinyl-vinyl coupling.
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Lead optimization of the VU0486321 series of mGlu(1) PAMs. Part 2: SAR of alternative 3-methyl heterocycles and progress towards an in vivo tool.
Pedro M. Garcia-Barrantes,Hyekyung P. Cho,Hyekyung P. Cho,Adam M. Metts,Anna L. Blobaum,Colleen M. Niswender,Colleen M. Niswender,P. Jeffrey Conn,P. Jeffrey Conn,Craig W. Lindsley,Craig W. Lindsley +10 more
TL;DR: This Letter describes the further lead optimization of the VU0486321 series of mGlu1 positive allosteric modulators (PAMs), driven by recent genetic data linking loss of function GRM1 to schizophrenia.
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