Craig Monger
Trinity College, Dublin
14 Papers
7 Citations
Craig Monger is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Chinese hamster ovary cell & RNA-Seq. The author has an hindex of 4, co-authored 9 publications. Previous affiliations of Craig Monger include Dublin City University & BlackRock.
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Papers
PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation.
Evan Healy,Marlena Mucha,Eleanor Glancy,Darren J. Fitzpatrick,Eric Conway,Hannah K. Neikes,Craig Monger,Guido van Mierlo,Marijke P. Baltissen,Yoko Koseki,Michiel Vermeulen,Haruhiko Koseki,Adrian P. Bracken +12 more
TL;DR: It is shown that PRC2.1 and PRC1.2 share the majority of target genes in mouse embryonic stem cells and a model in which the specific accessory proteins within PRC 2.2 cooperate to direct H3K27me3 via both synergistic and independent mechanisms is supported.
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Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
Gerard L. Brien,Raul Bardini Bressan,Raul Bardini Bressan,Craig Monger,Dáire Gannon,Eimear Lagan,Anthony M Doherty,Evan Healy,Hannah K. Neikes,Darren J. Fitzpatrick,Orla Deevy,Vivien Grant,Maria-Angeles Marqués-Torrejón,Neza Alfazema,Steven M. Pollard,Adrian P. Bracken +15 more
TL;DR: In this article, the authors used human hindbrain neural stem cells to model the consequences of H3.3-K27M on the epigenomic landscape in a relevant developmental context.
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Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.
Paul S. Kelly,Colin Clarke,Alan Costello,Craig Monger,Justine Meiller,Heena Dhiman,Nicole Borth,Michael J. Betenbaugh,Martin Clynes,Niall Barron +9 more
TL;DR: Experiments that integrate mtDNA sequencing with metabolic flux analysis and metabolomics have the potential to improve cell line selection and enhance CHO cell metabolic phenotypes for biopharmaceutical manufacturing through rational mitochondrial genome engineering.
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Subphysiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells
Ioanna Tzani,Craig Monger,Krishna Motheramgari,Clair Gallagher,Ryan Hagan,Paul S. Kelly,Alan Costello,Justine Meiller,Patrick Floris,Lin Zhang,Martin Clynes,Jonathan Bones,Niall Barron,Colin Clarke +13 more
TL;DR: This study demonstrates that alternative splicing analysis can be utilized to gain a deeper understanding of post‐transcriptional regulation in CHO cells during biopharmaceutical production.
Understanding biopharmaceutical production at single nucleotide resolution using ribosome footprint profiling.
TL;DR: RiboSeq is focused on, an exciting next generation sequencing (NGS) method that provides genome-wide information on translation, and how its application can transform the understanding of therapeutic protein production.
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