Corrinne M. Peterhoff
Nathan Kline Institute for Psychiatric Research
26 Papers
37 Citations
Corrinne M. Peterhoff is an academic researcher from Nathan Kline Institute for Psychiatric Research. The author has contributed to research in topics: Endosome & Presenilin. The author has an hindex of 21, co-authored 26 publications.
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Papers
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.
Ralph A. Nixon,Ralph A. Nixon,Jerzy Wegiel,Asok Kumar,Asok Kumar,Wai Haung Yu,Wai Haung Yu,Corrinne M. Peterhoff,Anne M. Cataldo,Anne M. Cataldo,Ana Maria Cuervo +10 more
TL;DR: This work unequivocally identified autophagosomes and other prelysosomal autophagic vacuoles (AVs), which were morphologically and biochemically similar to AVs highly purified from mouse liver, and provides the first evidence that macroautophagy is extensively involved in the neurodegenerative/regenerative process in AD.
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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
Ju-Hyun Lee,Ju-Hyun Lee,W. Haung Yu,W. Haung Yu,Asok Kumar,Asok Kumar,Sooyeon Lee,Sooyeon Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Corrinne M. Peterhoff,Devin M. Wolfe,Marta Martinez-Vicente,Ashish C. Massey,Guy Sovak,Yasuo Uchiyama,David Westaway,Ana Maria Cuervo,Ralph A. Nixon,Ralph A. Nixon +19 more
TL;DR: It is shown that macroautophagy requires the Alzheimer's disease-related protein presenilin-1 (PS1) for v-ATPase targeting to lysosomes, lysOSome acidification, and proteolysis during autophagy, which represents a basis for pathogenic protein accumulations and neuronal cell death in AD.
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Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
W. Haung Yu,Ana Maria Cuervo,Asok Kumar,Corrinne M. Peterhoff,Stephen D. Schmidt,Ju-Hyun Lee,Ju-Hyun Lee,Panaiyur S. Mohan,Panaiyur S. Mohan,Marc Mercken,Mark R. Farmery,Lars O. Tjernberg,Ying Jiang,Ying Jiang,Karen Duff,Karen Duff,Yasuo Uchiyama,Jan Näslund,Paul M. Mathews,Paul M. Mathews,Anne M. Cataldo,Ralph A. Nixon,Ralph A. Nixon +22 more
TL;DR: It is shown that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β- amyloidosis.
Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations
Anne M. Cataldo,Corrinne M. Peterhoff,Juan C. Troncoso,Teresa Gomez-Isla,Bradley T. Hyman,Ralph A. Nixon +5 more
TL;DR: Early endosomal abnormalities provide a mechanistic link between EP alterations, genetic susceptibility factors, and Abeta generation and suggest differences that may be involved in Abetageneration and beta amyloidogenesis in subtypes of AD.
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy.
Matteo Bordi,Martin J. Berg,Panaiyur S. Mohan,Corrinne M. Peterhoff,Melissa J. Alldred,Shaoli Che,Stephen D. Ginsberg,Ralph A. Nixon +7 more
TL;DR: It is proposed that sustained induction of autophagy in the face of progressively declining lysosomal clearance of substrates explains the uncommonly robust autophagic pathology and neuritic dystrophy implicated in AD pathogenesis.
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