Cornelia Kilchert
University of Giessen
9 Papers
28 Citations
Cornelia Kilchert is an academic researcher from University of Giessen. The author has contributed to research in topics: RNA & Exosome complex. The author has an hindex of 4, co-authored 9 publications.
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Papers
From parts lists to functional significance-RNA-protein interactions in gene regulation.
TL;DR: The challenges in combining molecular mechanism with cellular functions on the journey towards a comprehensive understanding of the regulatory functions of RNA–protein interactions in cells are discussed.
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System-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organization and function of RNA-protein complexes.
Cornelia Kilchert,Tea Kecman,Emily Priest,Svenja Hester,Ebru Aydin,Krzysztof Kus,Oliver Rossbach,Alfredo Castello,Shabaz Mohammed,Lidia Vasiljeva +9 more
TL;DR: Fission yeast whole-cell poly(A)+ RNA-protein crosslinking data provide information on the organization of RNA- protein complexes and it is proposed that the RNA-binding characteristics observed in fission yeast are likely to apply to related proteins in higher eukaryotes as well.
Comparative Poly(A)+ RNA Interactome Capture of RNA Surveillance Mutants.
TL;DR: Comparative poly(A)+ RNA interactome capture is described as a method to screen for novel RNA-binding proteins involved in exosome-dependent RNA decay and quantitatively compare the RNA-protein interactomes of wild-type and rrp6Δ cells to selectively determine cofactors of the nuclear RNA exosomes complex in fission yeast.
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System-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organisation and function of RNA-protein complexes
Cornelia Kilchert,Tea Kecman,Emily Priest,Svenja Hester,Krzysztof Kus,Alfredo Castello,Shabaz Mohammed,Lidia Vasiljeva +7 more
TL;DR: It is shown that fission yeast whole cell poly(A)+ RNA-protein crosslinking data provides system-wide information on the organisation and function of theRNA-protein complexes, and the central role of the RNA helicase Mtl1 in RNA degradation by the exosome is highlighted.
RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response.
Adrien Birot,Krzysztof Kus,Emily Priest,Ahmad Al Alwash,Alfredo Castello,Alfredo Castello,Shabaz Mohammed,Lidia Vasiljeva,Cornelia Kilchert +8 more
- 01 Feb 2022
TL;DR: In this article, the authors used comparative poly(A)+ RNA interactome capture in fission yeast expressing three different mutants of the exosome to identify proteins that interact with poly( A)+ RNA in an exosOME-dependent manner.
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