Corey M. McCann

TL;DR: Imaged the synapses between pre- and postganglionic neurons in the mouse submandibular ganglion in vivo, focusing on the mechanisms that maintain and regulate neurotransmitter receptor density at postsynaptic sites, to show that neurotransmitter receptors dynamism associated with rapid changes in synaptic efficacy precedes long-lasting structural change in synaptic connectivity.

TL;DR: In vivo methods to acquire three‐dimensional image stacks of the axons and postsynaptic sites and then follow them over time are developed to study the formation, elimination, and maintenance of synaptic connections between neurons in vivo.

TL;DR: It is shown that FMT-MR imaging can produce three-dimensional, multimodal images of living mouse brains allowing for serial monitoring of tumor morphology and protease activity, and that combined FMT and magnetic resonance imaging of fluorescent molecular probes could be valuable for brain tumor drug development and other neurological and somatic imaging applications.

TL;DR: This strategy for epitope tagging provides a useful adjunct to green fluorescent protein (GFP)-tagging, which fails to distinguish intracellular from extracellular pools, sometimes interferes with protein localization or function, and requires a separate construct for each color.