38 Papers
404 Citations
Cor Ras is an academic researcher from Delft University of Technology. The author has contributed to research in topics: Metabolite & Chemostat. The author has an hindex of 26, co-authored 38 publications.
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Papers
When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation
Made Tri Ari Penia Kresnowati,W.A. van Winden,Marinka J. H. Almering,A ten Pierick,Cor Ras,Theo A. Knijnenburg,Pascale Daran-Lapujade,Jack T. Pronk,J. J. Heijnen,J.M. Daran +9 more
TL;DR: The short‐term dynamics of the transcriptome revealed a remarkably fast decrease in the average half‐life of downregulated genes, which can be interpreted both as an additional nucleotide salvage pathway and an additional level of glucose‐induced regulation of gene expression.
Rapid sampling for analysis of in vivo kinetics using the BioScope: A system for continuous-pulse experiments
Diana Visser,Gertan A. van Zuylen,Jan C. van Dam,Arthur Oudshoorn,Michael R. Eman,Cor Ras,Walter M. van Gulik,Johannes Frank,Gijs W.K. van Dedem,Joseph J. Heijnen +9 more
TL;DR: Several system properties, including plug-flow characteristics, mixing, oxygen and carbon dioxide transfer rates, the quenching time, and the reproducibility have been explored, with satisfactory results.
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Analysis of in vivo kinetics of glycolysis in aerobic Saccharomyces cerevisiae by application of glucose and ethanol pulses.
Diana Visser,Gertan A. van Zuylen,Jan C. van Dam,Michael R. Eman,Angela Pröll,Cor Ras,Liang Wu,Walter M. van Gulik,Joseph J. Heijnen +8 more
TL;DR: The results confirm that FBP stimulates pyruvate kinase and suggest that this effect is pronounced, and it appears that PEP does not play an important role in the allosteric regulation of phosphofructo kinase.
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Metabolic flux analysis of a glycerol‐overproducing Saccharomyces cerevisiae strain based on GC‐MS, LC‐MS and NMR‐derived 13C‐labelling data
Roelco J. Kleijn,Jan-Maarten A. Geertman,Beckley K. Nfor,Cor Ras,Dick Schipper,Jack T. Pronk,Joseph J. Heijnen,Antonius J. A. van Maris,Wouter A. van Winden +8 more
TL;DR: The exchange flux of four-carbon dicarboxylic acids across the mitochondrial membrane, as measured by the 13C-labelling data, supports a possible role of a malate/aspartate or malates/oxaloacetate redox shuttle in the transfer of these redox equivalents from the cytosol to the mitochondrial matrix.
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Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae.
TL;DR: Oscillations in intracellular amino acids might be, at least partly, following oscillations of their anabolic precursors, as well as close correlation of the pool sizes of the involved metabolites, which might indicate that, in vivo, these reactions are operating close to equilibrium.
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