After having reviewed some aspects of microfluidic system preparation in the first part (1), in this second part of the review we will cover a number of standard operations (namely: sample preparation, sample injection, sample manipulation, reaction, separation, and detection) as well as some biological applications of micro total analysis systems (namely: cell culture, polymerase chain reaction, DNA separation, DNA sequencing, and clinical diagnostics). As previously, we will include papers issued from different scientific journals as well as useful abstracts from three conference proceedings: MEMS, Transducers, and μTAS. In this second part, we do not include the period covered by the history section (1975-1997) from part 1 but try to cover the relevant examples of the literature published between January 1998 and March 2002. We briefly describe articles that struck us as needing special attention, while more “standard” papers are dutifully reported in groups of interest. An article might be included in more than one section, depending on the ideas developed in it.

Micro total analysis systems. 2. Analytical standard operations and applications.

Atmospheric pressure plasmas: A review

Atmospheric-pressure, non-equilibrium plasmas are susceptible to instabilities and, in particular, to arcing (glow-to-arc transition). Spatially confining the plasma to dimensions of 1 mm or less is a promising approach to the generation and maintenance of stable, glow discharges at atmospheric-pressure. Often referred to as microdischarges or microplasmas, these weakly-ionized discharges represent a new and fascinating realm of plasma science, where issues such as the possible breakdown of 'pd scaling' and the role of boundary-dominated phenomena come to the fore. Microplasmas are generated under conditions that promote the efficient production of transient molecular species such as the rare gas excimers, which generally are formed by three-body collisions. Pulsed excitation on a sub-microsecond time scale results in microplasmas with significant shifts in both the temperatures and energy distribution functions associated with the ions and electrons. This allows for the selective production of chemically reactive species and opens the door to a wide range of new applications of microplasmas. The implementation of semiconductor and microelectronics and MEMs microfabrication techniques has resulted in the realization of microplasma arrays as large as 250,000 devices. Fabricated in silicon or ceramics with characteristic device dimensions as small as 10 µm and at packing densities up to 104 cm−2, these arrays offer optical and electrical characteristics well suited for applications in medical diagnostics, displays and environmental sensing. Several microplasma device structures, including their fundamental properties and selected applications, will be discussed.

Microplasmas and applications

Thanks to their portability and the non-equilibrium character of the discharges, microplasmas are finding application in many scientific disciplines. Although microplasma research has traditionally been application driven, microplasmas represent a new realm in plasma physics that still is not fully understood. This paper reviews existing microplasma sources and discusses charged particle kinetics in various microdischarges. The non-equilibrium character highlighted in this manuscript raises concerns about the accuracy of fluid models and should trigger further kinetic studies of high-pressure microdischarges. Finally, an outlook is presented on the biomedical application of microplasmas.

Microplasmas: sources, particle kinetics, and biomedical applications

Introduction Fundamental principles of inductively coupled plasmas Instrumentation for ICP-AES Aerosol generation and sample transport in plasma spectrometry Fundamental aspects of ICP-MS Use of ICP-MS for isotope ratio measurements Alternative plasmas and sample introduction systems Environmental applications of plasma spectrometry Geological applications of plasma spectrometry Applications of plasma spectrometry in food science References Index .

Inductively coupled plasma spectrometry and its applications

An optical emission plasma source with dimensions as small as 0.25 × 0.25 × 5 mm has been implemented on a quartz wafer. The He plasma, formed using a parallel plate, capacitively coupled geometry, operates at atmospheric pressure, uses a 13.56 MHz power source at 5–25 W, with gas flows between 17–150 mL min−1, and is self-igniting. Parallel-plate capacitive power coupling is nearly ideal for generating and sustaining a plasma discharge “on a chip” since it can be implemented using a very simple electrode structure and does not require tuned or resonant structures.

A capacitively coupled microplasma (CCµP) formed in a channel in a quartz wafer

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A capacitively coupled microplasma (CCµP) formed in a channel in a quartz wafer