Conor Stack

TL;DR: Experimental rats did not spontaneously discriminate similar odor pairs before the exposure period, whereas they spontaneously discriminated them after the enrichment period, and the improvement of performance was not selective for the odors used during enrichment.

TL;DR: It is shown that the perception of test odorants is only modulated by enrichment with odorants that activate at least partially overlapping regions of the olfactory bulb, and that blockade of NMDA receptors in the ofactory bulb impairs the effects of daily enrichment, suggesting that NMDA-dependent plasticity is involved in the changes in olf factory processing observed here.

TL;DR: It is found that, after the enrichment period, rats could discriminate components in binary mixtures that had not been discriminated prior to the enrichment Period, and that this increase in discrimination capability was not always specific to the odorants used during the enrichmentperiod.

TL;DR: Results provide proof of principle that noninvasive therapy based on the use of PACAP analogs is a therapeutic option for SBMA, and develop an analog of pituitary adenylyl cyclase activating polypeptide (PACAP), a potent activator of the AC/PKA pathway.