Conor R Walker
European Bioinformatics Institute
10 Papers
Conor R Walker is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Computer science & Biology. The author has an hindex of 4, co-authored 8 publications. Previous affiliations of Conor R Walker include University of Cambridge.
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Papers
A Phylodynamic Workflow to Rapidly Gain Insights into the Dispersal History and Dynamics of SARS-CoV-2 Lineages.
Simon Dellicour,Simon Dellicour,Keith Durkin,Samuel L. Hong,Bert Vanmechelen,Joan Martí-Carreras,Mandev S. Gill,Cécile Meex,Sébastien Bontems,Emmanuel André,Marius Gilbert,Conor R Walker,Nicola De Maio,Nuno R. Faria,Nuno R. Faria,James Hadfield,Marie-Pierre Hayette,Vincent Bours,Tony Wawina-Bokalanga,Maria Artesi,Guy Baele,Piet Maes +21 more
TL;DR: A rapid analytical pipeline is described and applied to analyze the spatiotemporal dispersal history and dynamics of SARS-CoV-2 lineages and has the potential to be quickly applied to other countries or regions, with key benefits in complementing epidemiological analyses in assessing the impact of intervention measures or their progressive easement.
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A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages
Simon Dellicour,Keith Durkin,Samuel L. Hong,Bert Vanmechelen,Joan Martí-Carreras,Mandev S. Gill,Cécile Meex,Sébastien Bontems,Emmanuel André,Marius Gilbert,Conor R Walker,Nicola De Maio,James Hadfield,Marie-Pierre Hayette,Vincent Bours,Tony Wawina-Bokalanga,Maria Artesi,Guy Baele,Piet Maes +18 more
TL;DR: An analytical pipeline is described and applied that is a compromise between fast and rigorous analytical steps and has the potential to be quickly applied to other countries or regions, with key benefits in complementing epidemiological analyses in assessing the impact of intervention measures or their progressive easement.
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Short-range template switching in great ape genomes explored using pair hidden Markov models.
TL;DR: In this article, an improved statistical approach using pair hidden Markov models is presented to detect and describe short-range template switches underlying clusters of mutations in the multi-way alignment of hominid genomes.
phastSim: efficient simulation of sequence evolution for pandemic-scale datasets
De Maio N,Lukas Weilguny,Conor R Walker,Conor R Walker,Yatish Turakhia,Russell Corbett-Detig,Nick Goldman +6 more
TL;DR: PhastSim as mentioned in this paper is based on the Gillespie approach, and implements an efficient multi-layered search tree structure that provides high computational efficiency by taking advantage of the fact that only a small proportion of the genome is likely to mutate at each branch of the considered phylogeny.
Modelling the impact of hybrid immunity on future COVID-19 epidemic waves
Thong P. Le,I. Abell,Eamon J Conway,Patricia T. Campbell,Alexandra B. Hogan,Michael J. Lydeamore,Jodie McVernon,Ivo Mueller,Conor R Walker,Christopher M. Baker +9 more
TL;DR: In this paper , the authors explore how different combinations of hybrid immunity affect the size and severity of near-future Omicron waves, and they use an agent-based model of COVID-19 transmission with waning immunity to simulate outbreaks in populations with varied past attack rates and past vaccine coverages.