Connie J. Eaves
BC Cancer Agency
487 Papers
7.2K Citations
Connie J. Eaves is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 106, co-authored 474 publications. Previous affiliations of Connie J. Eaves include Erasmus University Rotterdam & University of Hong Kong.
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Papers
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
Michael F. Clarke,John E. Dick,Peter B. Dirks,Connie J. Eaves,Catriona Jamieson,D. Leanne Jones,Jane E. Visvader,Irving L. Weissman,Geoffrey M. Wahl +8 more
TL;DR: A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression, and participants were charged with evaluating data suggesting that cancers develop from a small subset of cells with self-renewal properties analogous to organ regeneration.
3.2K
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah,Andrew Roth,Rodrigo Goya,Arusha Oloumi,Gavin Ha,Yongjun Zhao,Gulisa Turashvili,Jiarui Ding,Kane Tse,Gholamreza Haffari,Ali Bashashati,Leah M Prentice,Jaswinder Khattra,Angela Burleigh,Damian Yap,Virginie Bernard,Andrew McPherson,Karey Shumansky,Anamaria Crisan,Ryan Giuliany,Alireza Heravi-Moussavi,Jamie Rosner,Daniel Lai,Inanc Birol,Richard Varhol,Angela Tam,Noreen Dhalla,Thomas Zeng,Kevin C. Ma,Simon K. Chan,Malachi Griffith,Annie Moradian,S.-W. Grace Cheng,Gregg B. Morin,Peter H. Watson,Karen A. Gelmon,Stephen Chia,Suet-Feung Chin,Christina Curtis,Christina Curtis,Oscar M. Rueda,Paul D.P. Pharoah,Sambasivarao Damaraju,John R. Mackey,Kelly Hoon,Timothy T. Harkins,Vasisht Tadigotla,Mahvash Sigaroudinia,Philippe Gascard,Thea D. Tlsty,Joseph F. Costello,Irmtraud M. Meyer,Connie J. Eaves,Wyeth W. Wasserman,Steven J.M. Jones,Steven J.M. Jones,David G. Huntsman,David G. Huntsman,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio +61 more
TL;DR: It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
Purification and unique properties of mammary epithelial stem cells
John Stingl,Peter Eirew,Ian Ricketson,Mark Shackleton,François Vaillant,David H. Choi,Haiyan I. Li,Connie J. Eaves,Connie J. Eaves +8 more
TL;DR: The use of multi-parameter cell sorting and limiting dilution transplant analysis is reported to demonstrate the purification of a rare subset of adult mouse mammary cells that are able individually to regenerate an entire mammary gland within 6 weeks in vivo while simultaneously executing up to ten symmetrical self-renewal divisions.
1.6K
Cancer stem cells: an evolving concept
TL;DR: New insights are obtained into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.
1.2K
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.
Ryan D. Morin,Michael D O'Connor,Malachi Griffith,Florian Kuchenbauer,Allen Delaney,Anna-Liisa Prabhu,Yongjun Zhao,Helen McDonald,Thomas Zeng,Martin Hirst,Connie J. Eaves,Marco A. Marra +11 more
TL;DR: Application of this approach to RNA from human embryonic stem cells obtained before and after their differentiation into embryoid bodies revealed the sequences and expression levels of 334 known plus 104 novel miRNA genes, representing the deepest miRNA sampling to date.