Conner Kummerlowe
5 Papers
13 Citations
Conner Kummerlowe is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 5 publications.
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Papers
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
Hannah P. Gideon,Travis K. Hughes,Constantine N. Tzouanas,Marc H. Wadsworth,Ang A. Tu,Todd M. Gierahn,Joshua Peters,Forrest F. Hopkins,Jun-Rong Wei,Conner Kummerlowe,Nicole L. Grant,Kievershen Nargan,Jia Yao Phuah,H. J. Borish,Pauline Maiello,Alexander G. White,Caylin G. Winchell,Sarah K. Nyquist,Sharie Keanne C. Ganchua,Amy J. Myers,K V Patel,Cassaundra Ameel,Catherine Cochran,Samira Ibrahim,Jaime Tomko,L. James Frye,Jacob M. Rosenberg,Angela R. Shih,Michael Chao,Edwin Klein,Charles A. Scanga,Jose Ordovas-Montanes,Bonnie Berger,Joshua T. Mattila,Rajhmun Madansein,J. Christopher Love,Philana Ling Lin,Alasdair Leslie,Samuel M. Behar,Bryan D. Bryson,JoAnne L. Flynn,Sarah M. Fortune,Alex K. Shalek +42 more
TL;DR: The authors identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance.
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Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Benjamin E. Mead,Kazuki Hattori,Lauren Levy,Shinya Imada,Norihiro Goto,Marko Vukovic,Daphne Sze,Conner Kummerlowe,Juan D. Matute,Jinzhi Duan,Robert Langer,Richard S. Blumberg,Jose Ordovas-Montanes,Ömer H. Yilmaz,Jeffrey M. Karp,Alex K. Shalek +15 more
TL;DR: In this article , the authors identify druggable biological targets and small-molecule regulators of intestinal stem cell differentiation via multiplexed phenotypic screening using thousands of miniaturized organoid models.
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation
Conner Kummerlowe,Simutanyi Mwakamui,Travis K. Hughes,Nolawit Mulugeta,Victor Mudenda,Ellen Besa,Kanekwa Zyambo,Jessica E.S. Shay,Ira Fleming,Marko Vukovic,Benjamin Doran,Toby Aicher,Marc H. Wadsworth,Juliet Bramante,Amiko M. Uchida,Rabiah Fardoos,Osaretin E. Asowata,N. Herbert,Ömer H. Yilmaz,Henrik N. Kløverpris,John J. Garber,Jose Ordovas-Montanes,Zev J. Gartner,Thomas Dr. Wallach,Alex K. Shalek,Paul J. Kelly +25 more
TL;DR: The cellular and molecular correlates of EE are mapped by performing high-throughput, single-cell RNA-sequencing on 33 small intestinal biopsies from 11 adults with EE in Lusaka, Zambia, six adults without EE in Boston, United States, and two adults in Durban, South Africa, which are complemented with published data from three additional individuals from the same clinical site.
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Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation
Benjamin E. Mead,Kazuki Hattori,Lauren Levy,Shinya Imada,Norihiro Goto,Marko Vukovic,Daphne Sze,Conner Kummerlowe,Juan D. Matute,Jinzhi Duan,Robert Langer,Richard S. Blumberg,Jose Ordovas-Montanes,Ömer H. Yilmaz,Jeffrey M. Karp,Alex K. Shalek +15 more
TL;DR: In this article , the authors identify druggable biological targets and small-molecule regulators of intestinal stem cell differentiation via multiplexed phenotypic screening using thousands of miniaturized organoid models.
Compressed phenotypic screens for complex multicellular models and high-content assays
Benjamin E. Mead,Conner Kummerlowe,Nuo Liu,Walaa E Kattan,Thomas Cheng,Jaime H. Cheah,Christian K. Soule,Joshua Peters,Kristen E. Lowder,Paul C. Blainey,William C. Hahn,Brian Cleary,Bryan D. Bryson,Peter S. Winter,Srivatsan Raghavan,Alex K. Shalek +15 more
TL;DR: In this article , a method for compressing screens by pooling perturbations followed by computational deconvolution is proposed to examine transcriptional responses of pancreatic cancer organoids to a library of tumor-microenvironment (TME)-nominated recombinant protein ligands.