6 Papers
21 Citations
Cong Yu is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Induced pluripotent stem cell & Neurodegeneration. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Cong Yu include University at Buffalo & University of Tübingen.
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Papers
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease.
David C. Schöndorf,David C. Schöndorf,Dina Ivanyuk,Dina Ivanyuk,Pascale Baden,Pascale Baden,Alvaro Sanchez-Martinez,Silvia De Cicco,Silvia De Cicco,Cong Yu,Cong Yu,Ivana Giunta,Lukas Kristoffer Schwarz,Lukas Kristoffer Schwarz,Gabriele Di Napoli,Gabriele Di Napoli,Vasiliki Panagiotakopoulou,Vasiliki Panagiotakopoulou,Sigrun Nestel,Marcus Keatinge,Jan Pruszak,Oliver Bandmann,Bernd Heimrich,Thomas Gasser,Thomas Gasser,Alexander J. Whitworth,Michela Deleidi,Michela Deleidi +27 more
TL;DR: It is reported that increasing NAD+ via the NAD+ precursor nicotinamide riboside (NR) significantly ameliorates mitochondrial function in patient neurons, suggesting NR as a viable clinical avenue for neuroprotection in PD and other neurodegenerative diseases.
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Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells.
Vasiliki Panagiotakopoulou,Vasiliki Panagiotakopoulou,Dina Ivanyuk,Dina Ivanyuk,Silvia De Cicco,Silvia De Cicco,Wadood Haq,Aleksandra Arsić,Cong Yu,Cong Yu,Daria Messelodi,Daria Messelodi,Marvin Oldrati,Marvin Oldrati,David C. Schöndorf,David C. Schöndorf,Maria-Jose Perez,Maria-Jose Perez,Ruggiero Pio Cassatella,Ruggiero Pio Cassatella,Meike Jakobi,Nicole Schneiderhan-Marra,Thomas Gasser,Thomas Gasser,Ivana Nikić-Spiegel,Michela Deleidi,Michela Deleidi +26 more
TL;DR: It is proposed that synergistic LRRK2/IFN-γ activation serves as a potential link between inflammation and neurodegeneration in Parkinson’s disease.
Genome editing in pluripotent stem cells: research and therapeutic applications.
TL;DR: An overview of the available genome editing systems is provided and opportunities and perspectives for their application in basic research and clinical practice are discussed, with a particular focus on hPSC based research and gene therapy approaches.
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Interferon-γ signaling synergizes with LRRK2 in human neurons and microglia
Silvia De Cicco,Silvia De Cicco,Dina Ivanyuk,Dina Ivanyuk,Wadood Haq,Vasiliki Panagiotakopoulou,Vasiliki Panagiotakopoulou,Aleksandra Arsić,David C. Schöndorf,David C. Schöndorf,Cong Yu,Cong Yu,Maria-Jose Perez,Maria-Jose Perez,Ruggiero Pio Cassatella,Ruggiero Pio Cassatella,Meike Jakobi,Nicole Schneiderhan-Marra,Ivana Nikić-Spiegel,Thomas Gasser,Thomas Gasser,Michela Deleidi,Michela Deleidi +22 more
TL;DR: It is proposed that synergistic IFN-γ/LRRK2 activation serves as a direct link between inflammation and neurodegeneration in PD.
Insights into GBA Parkinson's disease pathology and therapy with induced pluripotent stem cell model systems.
TL;DR: Findings that emerged from iPSC-based studies in the context of GBA-PD pathology and therapy are summarized and current advantages and challenges of stem cell models for neurological disease modeling and drug discovery are highlighted.