Colin W. Pouton
Monash University
221 Papers
3.5K Citations
Colin W. Pouton is an academic researcher from Monash University. The author has contributed to research in topics: Chemistry & Embryonic stem cell. The author has an hindex of 53, co-authored 211 publications. Previous affiliations of Colin W. Pouton include Monash University, Clayton campus & University of London.
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Papers
A comparison of the lung clearance kinetics of Solid lipid nanoparticles and Liposomes by following the 3H-labelled structural lipids after pulmonary delivery in rats
Shadabul Haque,Michael R. Whittaker,Michelle P. McIntosh,Colin W. Pouton,Simon Phipps,Lisa M. Kaminskas,Lisa M. Kaminskas +6 more
TL;DR: The data showed that SLNs and liposomes were cleared from the lungs at similar rates, despite SLNs being deposited after intratracheal instillation in the upper respiratory track, and primarily via the mucociliary escalator, but this process was more pronounced for SLNs.
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Cationic lipid-mediated transfection of differentiated Caco-2 cells: a filter culture model of gene delivery to a polarized epithelium.
TL;DR: Differentiated Caco-2 cells are a more appropriate model for gene-transfer studies to the intestinal epithelium because they demonstrate a resistance to transfection similar to that observed in vivo.
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Mechanism of Microtubule-facilitated Fast Track Nuclear Import
TL;DR: This work uses site-directed mutagenesis, live cell imaging, and direct IMP and MT binding assays to map the MTAS of PTHrP for the first time, finding that it is within a short modular region that overlaps with the IMPβ1-recognized nuclear localization signal of P THrP.
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Digestion of Phospholipids after Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components
Woldeamanuel A. Birru,Dallas B. Warren,Ahmed M H Ibrahim,Hywel David Williams,Hassan Benameur,Christopher J.H. Porter,David K. Chalmers,Colin W. Pouton +7 more
TL;DR: It is suggested that mixtures of lysolecithin, fatty acid, and bile salts are a better model of molecular associations in the gut lumen, and such mixtures could be used to better understand the interaction of drugs with the fat digestion and absorption pathway.
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•Journal Article
Harnessing nuclear localization pathways for transgene delivery.
TL;DR: Current knowledge of this import machinery for DNA sequence-specific nuclear import is reviewed and its exploitation by mammalian viruses is considered.
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