Colin R. F. Monks
Anschutz Medical Campus
9 Papers
54 Citations
Colin R. F. Monks is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Colin R. F. Monks include National Jewish Health.
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Papers
Three-dimensional segregation of supramolecular activation clusters in T cells
TL;DR: The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes.
Terri H. Finkel,G. Tudor-Williams,Nirmal K. Banda,Mark F. Cotton,Tyler J. Curiel,Colin R. F. Monks,Colin R. F. Monks,Timothy W. Baba,Timothy W. Baba,Ruth M. Ruprecht,Abraham Kupfer +10 more
TL;DR: It is shown, using in situ labelling of lymph nodes from HIV- infected children and SIV-infected macaques, that apoptosis occurs predominantly in bystander cells and not in the productively infected cells themselves, arguing that rational drug therapy may involve combination agents targeting viral replication in infected cells and apoptosis of uninfected cells.
988
Selective modulation of protein kinase C-Θ during T-cell activation
TL;DR: In vitro kinase activity assays of PKC immunoprecipitates from the conjugates of T cells and APCs showed a selective increase in the activity ofPKC-Θ, indicating that the translocated enzyme is active.
564
Patent
High throughput biological sample preparation device and methods for use thereof
Colin R. F. Monks,Karl Kilborn,Abraham Kupfer +2 more
- 12 Mar 1998
TL;DR: In this article, a novel biological sample preparation (BSP) device and a method of using such a device that enables inexpensive and flexible high-throughput sample preparation and visualization for microscopy, including high resolution, single or multi-label, 2-dimensional (2D) or 3D) fluorescence microscopic observation of biological samples, such as cultured cells.
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Three dimensional visualization of proteins in cellular interactions
Colin R. F. Monks,Patricia Crossno,George S. Davidson,Constantine Pavlakos,Abraham Kupfer,Cláudio T. Silva,Brian N. Wylie +6 more
- 27 Oct 1996
TL;DR: It is concluded that no single one of these approaches provides a complete solution for visualizing biological data, but in combination, their respective strengths complement one another to provide an understanding of the data.
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