Colin C. F. Blake

TL;DR: A model is developed which accounts for thyroid hormone-prealbumin structure-activity relationships and ultimately to predict and measure the relative binding affinities of four previously untested thyroid hormone analogues to prealbumin.

TL;DR: The interactions of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds with pre albumin, a model for the nuclear thyroid hormone receptor, have been studied with use of computer graphics and predictions made regarding relative binding affinities for such structures demonstrated that such compounds could be effective competitive binding ligands for thyroxine-specific binding sites in prealbumin.

TL;DR: In this article, the interactions of selected polychlorinated biphenyls (PCBs) with prealbumin have been studied with use of computer graphics and predictions made regarding relative binding affinities for such structures.

TL;DR: Phenylcarbamate 8a was more active than methyl analogue 8b, while the 4'-deoxy and 4'-epi phenylcarbamates 17 and 18 showed particularly high efficacy at optimal dose levels similar to that of doxorubicin.