Coby B. Carlson
Life Technologies
22 Papers
55 Citations
Coby B. Carlson is an academic researcher from Life Technologies. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Coby B. Carlson include University of Wisconsin-Madison & Invitrogen.
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Papers
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
Faye M. Drawnel,Stefano Boccardo,Michael Prummer,Frederic Delobel,Alexandra Graff,Michael Weber,Régine Gérard,Laura Badi,Tony Kam-Thong,Lei Bu,Xin Jiang,Jean-Christophe Hoflack,Anna Kiialainen,Elena Jeworutzki,Natsuyo Aoyama,Coby B. Carlson,Mark Burcin,Gianni Gromo,Markus Boehringer,Henning Stahlberg,Benjamin J. Hall,Maria Chiara Magnone,Kyle L. Kolaja,Kenneth R. Chien,Jacques Bailly,Roberto Iacone +25 more
TL;DR: A patient-specific induced pluripotent stem cell (iPSC) model of a complex metabolic condition is presented, showing the power of this technique for discovery and testing of therapeutic strategies for a disease with ever-increasing clinical significance.
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Functional Characterization of an Isoform-Selective Inhibitor of PI3K-p110β as a Potential Anticancer Agent
Jing Ni,Qingsong Liu,Shaozhen Xie,Coby B. Carlson,Thanh Von,Kurt W. Vogel,Steve Riddle,Cyril H. Benes,Michael J. Eck,Thomas M. Roberts,Nathanael S. Gray,Jean J. Zhao +11 more
TL;DR: The first functional characterization of a p110β-selective inhibitor, KIN-193, that is efficacious as an antitumor agent in mice is reported, providing the first pharmacologic evidence that PTEN-deficient tumors are dependent on p110 β in animals.
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Phenotypic Characterization of Toxic Compound Effects on Liver Spheroids Derived from iPSC Using Confocal Imaging and Three-Dimensional Image Analysis.
Oksana Sirenko,Michael K. Hancock,Jayne Hesley,Dihui Hong,Avrum Cohen,Jason Gentry,Coby B. Carlson,David A. Mann +7 more
TL;DR: The results indicate that a phenotypic assay using 3D model systems formed with human iPSC-derived hepatocytes is suitable for high-throughput screening and can be used for hepatotoxicity assessment in vitro.
Bifunctional Ligands that Target Cells Displaying the αvβ3 Integrin
Robert M. Owen,Coby B. Carlson,Jinwang Xu,Patricia Mowery,Elisabetta Fasella,Laura L. Kiessling +5 more
TL;DR: This work describes the synthesis of bifunctional ligands possessing two functional motifs: one binds a cell‐surface protein and the other binds a naturally occurring human antibody, which can facilitate the development of new methods for targeting cancer cells by exploiting endogenous antibodies.
68
Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes.
Daniel C. Millard,Christopher J. Strock,Coby B. Carlson,Natsuyo Aoyama,Krisztina Juhasz,Tom A. Goetze,Sonja Stoelzle-Feix,Nadine Becker,Niels Fertig,Craig T. January,Blake D. Anson,James D. Ross +11 more
TL;DR: Mechanistic studies support hiPSC-CMs as a comprehensive, yet scalable model system for the identification and evaluation of cardioactive pharmacodynamic drug-drug interactions.
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