Clifford R. Jack
Mayo Clinic
1156 Papers
5.8K Citations
Clifford R. Jack is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 140, co-authored 965 publications. Previous affiliations of Clifford R. Jack include Medical University of South Carolina & Wellcome Trust Centre for Neuroimaging.
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Papers
Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia
Clifford R. Jack,Heather J. Wiste,Terry M. Therneau,Stephen D. Weigand,David S. Knopman,Michelle M. Mielke,Val J. Lowe,Prashanthi Vemuri,Mary M. Machulda,Christopher G. Schwarz,Jeffrey L. Gunter,Matthew L. Senjem,Jonathan Graff-Radford,David T.W. Jones,Rosebud O. Roberts,Walter A. Rocca,Ronald C. Petersen +16 more
TL;DR: A prediction model that included amyloid PET, tau PET, and MRI cortical thickness resulted in a small but statistically significant improvement in predicting memory decline over a model with more readily available clinical and genetic variables.
Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls.
Jonathan H. Morra,Zhuowen Tu,Liana G. Apostolova,Amity E. Green,Christina Avedissian,Sarah K. Madsen,Neelroop N. Parikshak,Arthur W. Toga,Clifford R. Jack,Norbert Schuff,Michael W. Weiner,Paul M. Thompson +11 more
TL;DR: 3D hippocampal volume loss rates increased with worsening diagnosis, and correlated with both baseline and interval changes in Mini-Mental State Examination (MMSE) scores and global and sum-of-boxes Clinical Dementia Rating scale (CDR) scores.
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A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
April J. Ho,Jason L. Stein,Xue Hua,Suh Lee,Derrek P. Hibar,Alex D. Leow,Ivo D. Dinov,Arthur W. Toga,Andrew J. Saykin,Li Shen,Tatiana Foroud,Nathan Pankratz,Matthew J. Huentelman,David Craig,Jill D. Gerber,April N. Allen,Jason J. Corneveaux,Dietrich A. Stephan,Charles DeCarli,Bryan M. DeChairo,Steven G. Potkin,Clifford R. Jack,Michael Weiner,Michael Weiner,Cyrus A. Raji,Oscar L. Lopez,James T. Becker,Owen Carmichael,Paul M. Thompson +28 more
TL;DR: 3D maps of regional brain volume differences in 206 healthy elderly subjects scanned with MRI and genotyped as part of the Alzheimer's Disease Neuroimaging Initiative reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly.
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
Rik Ossenkoppele,Alexa Pichet Binette,Colin Groot,Ruben Smith,Olof Strandberg,Sebastian Palmqvist,Erik Stomrud,Pontus Tideman,Tomas Ohlsson,Jonas Jögi,Keith A. Johnson,Reisa A. Sperling,Vincent Dorcet,Colin L. Masters,Christopher C. Rowe,Denise Visser,Bart N.M. van Berckel,Wiesje M. van der Flier,Suzanne L. Baker,William J. Jagust,Heather J. Wiste,Ronald C. Petersen,Clifford R. Jack,Oskar Hansson +23 more
TL;DR: In this paper , the authors examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A + ) and tau PETpositive (T + ) in the medial temporal lobe and/or in the temporal neocortex, and compared them with A + T − and A − T − groups.
Mild cognitive impairment due to Alzheimer disease in the community
Ronald C. Petersen,Paul S. Aisen,Bradley F. Boeve,Yonas E. Geda,Robert J. Ivnik,David S. Knopman,Michelle M. Mielke,Vernon S. Pankratz,Rosebud O. Roberts,Walter A. Rocca,Stephen D. Weigand,Michael W. Weiner,Heather J. Wiste,Clifford R. Jack +13 more
TL;DR: The newly proposed National Institute on Aging–Alzheimer's Association (NIA‐AA) criteria for mild cognitive impairment (MCI) due to Alzheimer's disease suggest a combination of clinical features and biomarker measures, but their performance in the community is not known.