Clifford R. Jack
Mayo Clinic
1156 Papers
5.8K Citations
Clifford R. Jack is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 140, co-authored 965 publications. Previous affiliations of Clifford R. Jack include Medical University of South Carolina & Wellcome Trust Centre for Neuroimaging.
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Papers
Regional variability of imaging biomarkers in autosomal dominant Alzheimer’s disease
Tammie L.S. Benzinger,Tyler Blazey,Clifford R. Jack,Robert A. Koeppe,Yi Su,Chengjie Xiong,Marcus E. Raichle,Abraham Z. Snyder,Beau M. Ances,Randall J. Bateman,Nigel J. Cairns,Anne M. Fagan,Alison Goate,Daniel S. Marcus,Paul S. Aisen,Jon Christensen,Lindsay Ercole,Russ C. Hornbeck,Angela M. Farrar,Patricia Aldea,Mateusz S. Jasielec,Christopher J. Owen,Xianyun Xie,Richard Mayeux,Adam M. Brickman,Eric McDade,William E. Klunk,Chester A. Mathis,John M. Ringman,Paul M. Thompson,Bernardino Ghetti,Andrew J. Saykin,Reisa A. Sperling,Keith A. Johnson,Stephen Salloway,Stephen Correia,Peter R. Schofield,Peter R. Schofield,Colin L. Masters,Christopher C. Rowe,Victor L. Villemagne,Ralph N. Martins,Sebastien Ourselin,Martin N. Rossor,Nick C. Fox,David M. Cash,Michael W. Weiner,David M. Holtzman,Virginia Buckles,Krista L. Moulder,John C. Morris +50 more
TL;DR: An integrated whole-brain analysis of three major imaging techniques found that most gray-matter structures with amyloid plaques later have hypometabolism followed by atrophy, and a hypermetabolic phase was identified for some cortical regions, including the precuneus and posterior cingulate.
A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity.
Christopher G. Schwarz,Jeffrey L. Gunter,Heather J. Wiste,Scott A. Przybelski,Stephen D. Weigand,Chadwick P. Ward,Matthew L. Senjem,Prashanthi Vemuri,Melissa E. Murray,Dennis W. Dickson,Joseph E. Parisi,Kejal Kantarci,Michael W. Weiner,Ronald C. Petersen,Clifford R. Jack +14 more
TL;DR: It is shown that volume- and thickness-based measures generally perform similarly for separating clinically normal from AD populations, and in correlation with Braak neurofibrillary tangle stage at autopsy.
363
Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study
Clifford R. Jack,Heather J. Wiste,Stephen D. Weigand,Walter A. Rocca,David S. Knopman,Michelle M. Mielke,Val J. Lowe,Matthew L. Senjem,Jeffrey L. Gunter,Gregory M. Preboske,Vernon S. Pankratz,Prashanthi Vemuri,Ronald C. Petersen +12 more
TL;DR: Changes in the frequency of amyloidosis and neurodegeneration with age, which seem to be modified by APOE ɛ4 and sex, suggest that pathophysiological sequences might differ between individuals.
Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography.
Matthew C. Murphy,John Huston,Clifford R. Jack,Kevin J. Glaser,Armando Manduca,Joel P. Felmlee,Richard L. Ehman +6 more
TL;DR: To test patient acceptance and reproducibility of the 3D magnetic resonance elastography (MRE) brain exam using a soft vibration source, and to determine if MRE could noninvasively measure a change in the elastic properties of the brain parenchyma due to Alzheimer's disease (AD).
352
Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer's disease
Jennifer L. Whitwell,Stephen D. Weigand,Maria M. Shiung,Bradley F. Boeve,Tanis J. Ferman,Glenn E. Smith,David S. Knopman,Ronald C. Petersen,Eduardo E. Benarroch,Keith A. Josephs,Clifford R. Jack +10 more
TL;DR: A pattern of relatively focused atrophy of the midbrain, hypothalamus and SI, with a relative sparing of the hippocampus and temporoparietal cortex is suggestive of DLB and this may aid in the differentiation ofDLB from Alzheimer's disease.