Clifford J. Rosen
Maine Medical Center
717 Papers
6.3K Citations
Clifford J. Rosen is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Osteoporosis & Bone density. The author has an hindex of 111, co-authored 655 publications. Previous affiliations of Clifford J. Rosen include Veterans Health Administration & Thomas Jefferson University.
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Papers
Skeletal unloading induces resistance to insulin-like growth factor I on bone formation.
Takeshi Sakata,Bernard P. Halloran,Hashem Z Elalieh,Scott Munson,Lanny J. Rudner,Laura L. Venton,David G. Ginzinger,Clifford J. Rosen,Daniel D. Bikle +8 more
TL;DR: Results indicate that skeletal unloading induces resistance to IGF-I on bone formation, as indicated by the reduction in osteogenic colony number, total ALP activity, and total mineralization in bone marrow osteoprogenitor cells of normally loaded rats.
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Congenic Mice Reveal Sex-Specific Genetic Regulation of Femoral Structure and Strength
Charles H. Turner,Qiwei Sun,J. Schriefer,N. Pitner,R. Price,Mary L. Bouxsein,Clifford J. Rosen,L. R. Donahue,K. L. Shultz,Wesley G. Beamer +9 more
TL;DR: It is concluded that chromosomal QTL from C3H mice, which are genetically linked to total femoral vBMD, also regulate femoral structure; the QTL on Chr 4 improves Femoral structure and strength; and the Q TL on Chr 6 imparts a sex-specific effect on cortical v BMD and femoral strength.
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Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society.
Josefine Tratwal,Rossella Labella,Nathalie Bravenboer,Nathalie Bravenboer,Greet Kerckhofs,Greet Kerckhofs,Eleni Douni,Erica L. Scheller,Sammy Badr,Dimitrios C. Karampinos,Sarah Beck-Cormier,Biagio Palmisano,Antonella Poloni,María J. Moreno-Aliaga,Jackie A. Fretz,Matthew S. Rodeheffer,Parastoo Boroumand,Clifford J. Rosen,Mark C. Horowitz,Bram C. J. van der Eerden,Annegreet G Veldhuis-Vlug,Annegreet G Veldhuis-Vlug,Olaia Naveiras +22 more
TL;DR: A working group to evaluate methodologies in bone marrow adiposity research advocates for the harmonization of methodologies, the precise reporting of known confounding factors, and the identification of methods to modulate BMA independently from other tissues.
The Transcription Factor Paired-Related Homeobox 1 (Prrx1) Inhibits Adipogenesis by Activating Transforming Growth Factor-β (TGFβ) Signaling
Baowen Du,William P. Cawthorn,Alison Su,Casey R. Doucette,Yao Yao,Nahid Hemati,Sarah E. Kampert,Colin S. McCoin,David T. Broome,Clifford J. Rosen,Gongshe Yang,Ormond A. MacDougald +11 more
TL;DR: The data support the hypothesis that endogenous Prrx1 restrains adipogenesis by regulating expression of TGFβ ligands and thereby activating TGF β signaling and contribute to aberrant adipocyte function during obesity.
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