Clifford J. Rosen
Maine Medical Center
717 Papers
6.3K Citations
Clifford J. Rosen is an academic researcher from Maine Medical Center. The author has contributed to research in topics: Osteoporosis & Bone density. The author has an hindex of 111, co-authored 655 publications. Previous affiliations of Clifford J. Rosen include Veterans Health Administration & Thomas Jefferson University.
Chat about Author
Papers
Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D
Mara J. Horwitz,Mary Beth Tedesco,Susan M. Sereika,Mushtaq A. Syed,Adolfo Garcia-Ocaña,Alessandro Bisello,Bruce W. Hollis,Clifford J. Rosen,John J. Wysolmerski,Pamela Dann,Caren M. Gundberg,Andrew F. Stewart +11 more
TL;DR: To model HPT and HHM, multiday continuous infusions of PTH versus PTHrP in humans results in marked and prolonged suppression of bone formation and renal 1,25(OH)2D synthesis was stimulated effectively by PTH but poorly by P THrP.
Tamoxifen and estrogen lower circulating lipoprotein(a) concentrations in healthy postmenopausal women.
David A. Shewmon,John L. Stock,Clifford J. Rosen,Kathleen M. Heiniluoma,Margaret M. Hogue,Anthony Morrison,Elizabeth M. Doyle,Thomas Ukena,Virginia Weale,Stephen P. Baker +9 more
TL;DR: Tamoxifen lowers plasma Lp(a) levels in healthy postmenopausal women, the suppressive effects of tamoxIFen and estrogen on circulating Lp (a) concentration diverge after the first month of therapy, and circulating levels of Lp.(a) and IGF-I are strongly correlated with each other, an indication that they may share regulatory influences.
Bone circuitry and interorgan skeletal crosstalk
Mone Zaidi,Se-Min Kim,Mehr Mathew,Funda Korkmaz,Farhath Sultana,Sari Miyashita,Anisa Gumerova,Tal Frolinger,Ofer Moldavski,Orly Barak,Anusha R. Pallapati,Satish Rojekar,John Caminis,Yelena Ginzburg,Vitaly Ryu,Terry F. Davies,Daria Lizneva,Clifford J. Rosen,Tony Yuen +18 more
TL;DR: Recently, it has become increasingly clear that bone cells, osteoblasts, osteoclasts, and osteocytes, communicate and regulate the fate of each other through RANK/RANKL/OPG, liver X receptors (LXRs), EphirinB2-EphB4 signaling, sphingolipids, and other membrane-associated proteins, such as semaphorins as discussed by the authors .
Addressing the Crisis in the Treatment of Osteoporosis: A Path Forward
Sundeep Khosla,Jane A. Cauley,Juliet E. Compston,Douglas P. Kiel,Clifford J. Rosen,Kenneth G. Saag,Elizabeth Shane +6 more
TL;DR: Improved patient and physician education on prodromal symptoms, extended femur scans using dual‐energy X‐ray absorptiometry (DXA) to monitor patients on antiresorptive treatment, better identification of high‐risk patients perhaps using geometrical parameters from DXA and other risk factors, and more research on pharmacogenomics to identify risk markers are suggested.
Dietary changes favorably affect bone remodeling in older adults.
Robert P. Heaney,David A. McCarron,Bess Dawson-Hughes,Suzanne Oparil,Sarah L. Berga,Judith S. Stern,Susan I. Barr,Clifford J. Rosen +7 more
TL;DR: The changes observed in the calcium economy through consumption of food sources of calcium are similar in kind and extent to those reported previously for calcium supplement tablets.