Clément Hoguin
French Institute of Health and Medical Research
7 Papers
Clément Hoguin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
Quitterie Venot,Thomas Blanc,Thomas Blanc,Thomas Blanc,Smail Hadj Rabia,Smail Hadj Rabia,Laureline Berteloot,Sophia Ladraa,J P Duong,J P Duong,Estelle Blanc,Simon C. Johnson,Clément Hoguin,Olivia Boccara,Sabine Sarnacki,Sabine Sarnacki,Nathalie Boddaert,Nathalie Boddaert,Stéphanie Pannier,Stéphanie Pannier,Frank Martinez,Sato Magassa,Junna Yamaguchi,Bertrand Knebelmann,Bertrand Knebelmann,Bertrand Knebelmann,Pierre Merville,Nicolas Grenier,Dominique Joly,Dominique Joly,Dominique Joly,Valérie Cormier-Daire,Valérie Cormier-Daire,Caroline Michot,Caroline Michot,Christine Bole-Feysot,Arnaud Picard,Arnaud Picard,Véronique Soupre,Stanislas Lyonnet,Stanislas Lyonnet,Jérémy Sadoine,Lotfi Slimani,Catherine Chaussain,Cécile Laroche-Raynaud,Laurent Guibaud,Christine Broissand,Jeanne Amiel,Jeanne Amiel,Christophe Legendre,Christophe Legendre,Christophe Legendre,Fabiola Terzi,Fabiola Terzi,Guillaume Canaud,Guillaume Canaud,Guillaume Canaud +56 more
TL;DR: This study provides the first direct evidence supporting PIK3CA inhibition as a promising therapeutic strategy in patients with PROS, by reversing symptoms in a mouse model of PROS/CLOVES syndrome, which results from gain-of-function mutations in PI3KCA.
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Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib
Gabriel Morin,Caroline Degrugillier-Chopinet,Marie Vincent,A. Fraissenon,Hélène Aubert,Célia Chapelle,Clément Hoguin,François Dubos,B. Catteau,Florence Petit,Aurélie Mezel,Olivia Domanski,Guillaume Herbreteau,Marie Alesandrini,Nathalie Boddaert,Nathalie Boutry,Christine Broissand,Tianxiang Kevin Han,Fabrice Branle,Sabine Sarnacki,Thomas Blanc,Laurent Guibaud,Guillaume Canaud +22 more
TL;DR: The authors report the first description of two infants with PIK3CA-related overgrowth spectrum treated by alpelisib, associated with clinical, biological, and radiological improvements.
PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption
Sophia Ladraa,Lola Zerbib,Charles Bayard,A. Fraissenon,Quitterie Venot,Gabriel Morin,Alexandre P. Garneau,Pierre Isnard,Célia Chapelle,Clément Hoguin,Sylvie Fraitag,J P Duong,Laurent Guibaud,Alix Besançon,Sophie Kaltenbach,Patrick Villarese,Vahid Asnafi,Christine Broissand,Nicolas Goudin,Michael Dussiot,Ivan Nemazanyy,Thomas Viel,Gwennhael Autret,Céline Cruciani-Guglielmacci,Jessica Denom,Julie Bruneau,Bertrand Tavitian,Christophe Legendre,Julien Dairou,Jean-Marc Lacorte,Pacifique Lévy,Mario Pende,Michael Pollak,Guillaume Canaud +33 more
TL;DR: In this paper , a mouse model of PIK3CA-related adipose tissue overgrowth was created to recapitulate patient phenotype and the mouse phenotype was mainly driven through AKT2.
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Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition.
Charles Bayard,Eleonora Segna,Maxime Taverne,A. Fraissenon,Quentin Hennocq,Baptiste Periou,Lola Zerbib,Sophia Ladraa,Célia Chapelle,Clément Hoguin,Sophie Kaltenbach,Patrick Villarese,Vahid Asnafi,Christine Broissand,Ivan Nemazanyy,Gwennhael Autret,Nicolas Goudin,Christophe Legendre,François-Jérôme Authier,Thomas Viel,Bertrand Tavitian,Cyril Gitiaux,Sylvie Fraitag,J P Duong,Clarisse Delcros,Bernard Sergent,Arnaud Picard,Michael Dussiot,Laurent Guibaud,Roman Khonsari,Guillaume Canaud +30 more
TL;DR: It is shown that HFMH is due to somatic alteration of PIK3CA and is accessible to pharmacological intervention and was able to prevent and reduce muscle hypertrophy in the mouse model with correction of endocrine anomalies.
4
PIK3CA Activation in Extracapillary Glomerulonephritis
Junna Yamaguchi,Pierre Isnard,Clément Hoguin,Aurélie Hummel,Guillaume Canaud +4 more
Abstract: ,